Document Detail


Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis.
MedLine Citation:
PMID:  17853184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Normal pregnancy is characterized by activation of the innate immunity and suppression of the adaptive limb of the immune response. However, pregnant women are more susceptible to the effects of infection and microbial products than non-pregnant women. CD30 is a member of the tumor necrosis factor receptor superfamily and is preferentially expressed by activated T cells producing Th2-type cytokines. Its soluble form (sCD30) is proposed to be an index of Th2 immune response. High serum concentrations of sCD30 have been found in the acute phase of viral infections, such as HIV-1 and hepatitis B. There is, however, conflicting evidence about serum sCD30 concentration in patients with bacterial infections. The objective of this study was to determine whether there are changes in the serum concentration of sCD30 in pregnant women with pyelonephritis.
METHODS: This cross-sectional study included normal pregnant women (N = 89) and pregnant women with pyelonephritis (N = 41). Maternal serum concentration of sCD30 was measured by a specific and sensitive enzyme-linked immunoassay. Non-parametric tests were used for comparisons. A p value <0.05 was considered statistically significant.
RESULTS: (1) Pregnant women with pyelonephritis had a significantly higher median serum concentration of sCD30 than those with a normal pregnancy (median 44.3 U/mL, range 16-352.5 vs. median 29.7 U/mL, range 12.2-313.2, respectively; p < 0.001), and (2) No significant differences were found in the median maternal serum concentration of sCD30 between pregnant women with pyelonephritis who had a positive blood culture compared to those with a negative blood culture (median 47.7 U/mL, range 17.1-118.8 vs. median 42.6 U/mL, range 16-352.5, respectively; p = 0.86).
CONCLUSIONS: Acute pyelonephritis during pregnancy is associated with a higher maternal serum concentration of sCD30 than normal pregnancy. This finding is novel and suggests that pregnant women with pyelonephritis may have a complex immune state in which there is activation of some components of what is considered a Th2 immune response.
Authors:
Juan Pedro Kusanovic; Roberto Romero; Jimmy Esoinoza; Francesca Gotsch; Samuel Edwin; Tinnakorn Chaiworapongsa; Pooja Mittal; Eleazar Soto; Offer Erez; Shali Mazaki-Tovi; Nandor Gabor Than; Lara A Friel; Bo Hyun Yoon; Moshe Mazor; Sonia S Hassan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  20     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-07     Completed Date:  2008-01-31     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  803-11     Citation Subset:  IM    
Affiliation:
Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD30 / blood*
Bacteremia / immunology
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Pregnancy
Pregnancy Complications, Infectious / blood*
Pyelonephritis / blood*,  complications*
Grant Support
ID/Acronym/Agency:
Z01 HD002400-16/HD/NICHD NIH HHS; Z99 HD999999/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD30
Comments/Corrections

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