| Maternal serum screening and trisomy 16 confined to the placenta. | |
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MedLine Citation:
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PMID: 8878276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five cases of trisomy 16 confined to the placenta have been detected by invasive procedures (amniocentesis and chorionic villus sampling) after high-risk results for Down syndrome and neural tube defects in a maternal serum screening programme of 6614 consecutive cases. All five pregnancies displayed unusually elevated levels of human chorionic gonadotropin and four out of five also had raised alpha-fetoprotein values. No structural malformation was present but all five pregnancies were complicated by fetal growth retardation, and one by intrauterine death. From our results, we suggest that both amniocentesis and chorionic villus sampling should be considered in the management of cases with high mid-trimester levels of these analytes. |
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Authors:
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C Groli; V Cerri; M Tarantini; D Bellotti; C Jacobello; R Gianello; R Zanini; S Lancetti; S Zaglio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 16 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-17 Completed Date: 1997-01-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 685-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Spedali Civili, Brescia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniocentesis Chorionic Gonadotropin / blood* Chorionic Villi Sampling Chromosomes, Human, Pair 16* Down Syndrome / blood Female Fetal Death / genetics Fetal Growth Retardation / genetics Humans Mosaicism* Neural Tube Defects / blood Placenta / chemistry* Pregnancy Prenatal Diagnosis* Trisomy* alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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