Document Detail

Maternal serum screening and trisomy 16 confined to the placenta.
MedLine Citation:
PMID:  8878276     Owner:  NLM     Status:  MEDLINE    
Five cases of trisomy 16 confined to the placenta have been detected by invasive procedures (amniocentesis and chorionic villus sampling) after high-risk results for Down syndrome and neural tube defects in a maternal serum screening programme of 6614 consecutive cases. All five pregnancies displayed unusually elevated levels of human chorionic gonadotropin and four out of five also had raised alpha-fetoprotein values. No structural malformation was present but all five pregnancies were complicated by fetal growth retardation, and one by intrauterine death. From our results, we suggest that both amniocentesis and chorionic villus sampling should be considered in the management of cases with high mid-trimester levels of these analytes.
C Groli; V Cerri; M Tarantini; D Bellotti; C Jacobello; R Gianello; R Zanini; S Lancetti; S Zaglio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  16     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  685-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Spedali Civili, Brescia, Italy.
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MeSH Terms
Chorionic Gonadotropin / blood*
Chorionic Villi Sampling
Chromosomes, Human, Pair 16*
Down Syndrome / blood
Fetal Death / genetics
Fetal Growth Retardation / genetics
Neural Tube Defects / blood
Placenta / chemistry*
Prenatal Diagnosis*
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins

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