Document Detail

Maternal serum screening for neural tube defects and fetal chromosome abnormalities.
MedLine Citation:
PMID:  7694429     Owner:  NLM     Status:  MEDLINE    
Second-trimester maternal serum screening is a noninvasive means of identifying pregnant women at an increased risk for various conditions including a fetus with open spina bifida, fetal Down syndrome, trisomy 18, multiple gestation, and adverse pregnancy outcome. Combinations of several different markers are available for screening. These include alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol. In this review, we discuss the benefits and limitations of the screening tests and the suggested protocols for the care of patients.
N C Rose; M T Mennuti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Western journal of medicine     Volume:  159     ISSN:  0093-0415     ISO Abbreviation:  West. J. Med.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-08     Completed Date:  1993-12-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0410504     Medline TA:  West J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-7     Citation Subset:  AIM; E; IM    
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104.
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MeSH Terms
Chorionic Gonadotropin / blood
Chromosome Aberrations / diagnosis*
Chromosome Disorders
Estriol / blood
Fetal Diseases / diagnosis*
Genetic Diseases, Inborn
Neural Tube Defects / diagnosis*
Pregnancy / blood
Pregnant Women*
Prenatal Diagnosis / methods*
Risk Assessment*
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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