Document Detail

Maternal serum screening for down syndrome in pregnancies conceived by intra-uterine insemination.
MedLine Citation:
PMID:  10589050     Owner:  NLM     Status:  MEDLINE    
The purpose of our study was to assess the influence of intra-uterine insemination (IUI) on the results of maternal serum Down syndrome screening. 43 women with IUI pregnancies and 4507 healthy women who conceived were studied. Ovulation in IUI pregnancies was induced by clomiphene and/or human menopausal gonadotrophin (hMG). Maternal serum levels of free beta-human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP) were measured for Down syndrome screening. It was considered screen-positive when the risk of Down syndrome was 1 in 270 or greater in the second trimester. The value of maternal serum AFP was significantly lower in the IUI group (median=0.760 MoM) than in the control group (median=1.050 MoM). However, the value of free beta-hCG was not significantly different between the two groups. The positive rate of maternal serum Down syndrome in IUI pregnancies was similar to that of the control group. Our results indicate that IUI pregnancy may be associated with a lower level of AFP, although the mechanism for this difference remains unknown.
T Y Hsu; C Y Ou; J J Hsu; F T Kung; S Y Chang; Y K Soong
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  19     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1012-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
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MeSH Terms
Case-Control Studies
Chorionic Gonadotropin, beta Subunit, Human / blood*
Down Syndrome / diagnosis*
Insemination, Artificial*
Maternal Age
Predictive Value of Tests
Pregnancy Outcome
Prenatal Diagnosis / standards*
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins

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