Document Detail


Maternal serum resistin concentrations in gestational diabetes mellitus and normal pregnancies.
MedLine Citation:
PMID:  21159034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate changes in maternal serum resistin levels during pregnancy and postpartum and clarify their relationship to insulin resistance.
METHODS: Thirty normal pregnant women were compared to 30 women diagnosed with gestational diabetes mellitus (GDM). Serum resistin levels were collected at the time of glucose challenge test (26-28 weeks), at 38 gestational weeks and at the third postpartum day and measured with enzyme immunoassay. Correlation of resistin to the homeostatic model assessment-insulin resistance (HOMA-IR) was performed.
RESULTS: Maternal serum resistin levels at 38 weeks were significantly higher in pregnant women with GDM compared to the control group (0.28 vs 0.21 ng/mL, P = 0.02) and the same was true for the immediate puerperium (0.25 vs 0.19 ng/mL, P = 0.03). A significant increase in resistin levels was observed in GDM women from 26-28 weeks to 38 weeks (0.21 vs 0.28 ng/mL, P = 0.02), but not in controls. A decrease in serum resistin levels was noted in both the GDM and control groups, at 38 weeks and the immediate postpartum period, but this decrease did not reach statistical significance in either of the two groups. Resistin levels were positively correlated to HOMA-IR at 26-28 weeks of gestation (r = +0.253, P = 0.05).
CONCLUSION: GDM is associated with increased resistin serum levels in term pregnancy as well as postpartum. Resistin is positively correlated to HOMA-IR at 26-28 weeks of gestation. A reduction in maternal resistin after delivery indicates a significant placental or fetal contribution in the production of resistin.
Authors:
Nikolaos Vitoratos; Aikaterini Deliveliotou; Alexandra Dimitrakaki; Dimitrios Hassiakos; Constantinos Panoulis; Efthimios Deligeoroglou; George K Creatsas
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Publication Detail:
Type:  Journal Article     Date:  2010-12-16
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  37     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-08-01     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  112-8     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.
Affiliation:
Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Diabetes, Gestational / blood*
Female
Humans
Insulin / analysis
Insulin Resistance / physiology
Postpartum Period / blood
Pregnancy
Resistin / blood*
Chemical
Reg. No./Substance:
0/Insulin; 0/Resistin

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