Document Detail


Maternal serum prostate-specific antigen and Down syndrome in the first and second trimesters of pregnancy. International Prenatal Screening Research Group.
MedLine Citation:
PMID:  10419619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that high levels of maternal serum prostate-specific (PSA) may be associated with fetal Down syndrome. We retrieved stored blood samples from 102 singleton Down syndrome pregnancies at 8-14 weeks' gestation and 99 at 15-22 weeks' gestation, together with samples from five unaffected singleton control pregnancies matched for gestational age. PSA was measured using an ultrasensitive assay. Contrary to earlier reports, PSA levels were similar in affected and unaffected pregnancies in both the first and second trimester of pregnancy; 1.1 and 0.9 multiple of the normal median, respectively, in affected pregnancies. There was no indication that PSA would be a useful screening marker.
Authors:
N J Wald; A K Hackshaw; E P Diamandis; D N Melegos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  19     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-19     Completed Date:  1999-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  674-6     Citation Subset:  IM    
Copyright Information:
Copyright 1999 John Wiley & Sons, Ltd.
Affiliation:
Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St. Bartholomews and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, U.K. n.j.wald@mds.qmw.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Down Syndrome / blood,  diagnosis*
Female
Gestational Age*
Humans
Pregnancy
Prenatal Diagnosis*
Prostate-Specific Antigen / blood*
Sensitivity and Specificity
Chemical
Reg. No./Substance:
EC 3.4.21.77/Prostate-Specific Antigen

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