Document Detail

Maternal serum progesterone, 17 beta-estradiol and estriol are increased in pregnancies which follow treatment with human menopausal gonadotropins: effects of multiple gestation and maternal endocrine status.
MedLine Citation:
PMID:  3927064     Owner:  NLM     Status:  MEDLINE    
A high incidence of premature labor, incompetent cervix and fetal wastage occurs in multiple gestations which follow treatment with human menopausal gonadotropins (HMG). In order to determine the effect of treatment with HMG on hormone secretion in human pregnancy, progesterone (PROG), 17 beta-estradiol (E2), estriol (E3) and human chorionic gonadotropin (hCG) were determined by radioimmunoassay in 341 serum specimens from 229 normal singleton pregnancies and in 79 serum specimens from 20 pregnancies following induction of ovulation with HMG in women with either hypothalamic amenorrhea (HA) or the polycystic ovary syndrome (PCO). Fitting equations were found for the log transformed normal values and the residuals were obtained by subtraction of the predicted normal values from the log transformed values observed in the HMG pregnancies. In pregnancies which followed treatment with HMG, PROG and E2 were initially elevated above normal. As pregnancy progressed, the deviation from normal became proportionately less. PROG (P less than 0.025) was lower and E2 (P less than 0.025) and E3 (P less than 0.05) were higher in PCO pregnancies than in HA pregnancies. Multiple gestation produced increases in PROG (P less than 0.005), E2 (P less than 0.005) and E3 (P less than 0.001) in comparison to singleton pregnancies.
R V Haning; A J Kiggens; T L Leiheit
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of steroid biochemistry     Volume:  22     ISSN:  0022-4731     ISO Abbreviation:  J. Steroid Biochem.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-09-13     Completed Date:  1985-09-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0260125     Medline TA:  J Steroid Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  823-9     Citation Subset:  IM    
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MeSH Terms
Amenorrhea / drug therapy
Chorionic Gonadotropin / blood
Estradiol / blood*
Estriol / blood*
Menotropins / adverse effects*,  therapeutic use
Ovulation Induction
Polycystic Ovary Syndrome / drug therapy
Pregnancy, Multiple*
Progesterone / blood*
Statistics as Topic
Time Factors
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-27-1/Estriol; 50-28-2/Estradiol; 57-83-0/Progesterone; 61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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