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Maternal serum placental growth factor at 11-13 weeks' gestation and fetal cardiac defects.
MedLine Citation:
PMID:  23151971     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To investigate the relation between fetal heart defects and maternal serum placental growth factor (PlGF), a marker of placental angiogenesis, because animal models demonstrated an association between angiogenesis and abnormal heart development. Methods: Maternal serum PLGF, pregnancy associated plasma protein-A (PAPP-A) and uterine artery pulsatility index (PI) at 11-13 weeks' gestation were compared in 68 cases of isolated fetal major heart defects and 340 normal controls. Results: In the heart defect group, compared to controls, the median PlGF multiple of median (MoM) was lower (0.80, IQR 0.57-1.08 vs. 1.00, IQR 0.79-1.32), but there was no significant difference in PAPP-A MoM (0.95, IQR 0.68-1.28 vs. 1.01, IQR 0.70-1.39) or uterine artery PI MoM (0.99, IQR 0.80-1.20 vs. 1.01, IQR 0.84-1.28). Conclusion: In pregnancies with isolated fetal heart defects there is evidence of impaired placental angiogenesis in the absence of impaired placental perfusion and function. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
E Llurba; A Syngelaki; O Sánchez; E Carreras; L Cabero; Kh Nicolaides
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Obstetrics, Maternal-Fetal Medicine Unit, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. Maternal and Child Health and Development Network (SAMID) RD 08/0072, Instituto de Salud Carlos III, Spain; Biochemistry and Molecular Biology Research Center for Nanomedicine, Vall Hebron University Hospital, Barcelona, Spain. Maternal and Child Health and Development Network (SAMID) RD 08/0072. Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain. ellurba@vhebron.net.
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