| Maternal serum placental growth factor at 11-13 weeks' gestation and fetal cardiac defects. | |
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MedLine Citation:
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PMID: 23151971 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To investigate the relation between fetal heart defects and maternal serum placental growth factor (PlGF), a marker of placental angiogenesis, because animal models demonstrated an association between angiogenesis and abnormal heart development. Methods: Maternal serum PLGF, pregnancy associated plasma protein-A (PAPP-A) and uterine artery pulsatility index (PI) at 11-13 weeks' gestation were compared in 68 cases of isolated fetal major heart defects and 340 normal controls. Results: In the heart defect group, compared to controls, the median PlGF multiple of median (MoM) was lower (0.80, IQR 0.57-1.08 vs. 1.00, IQR 0.79-1.32), but there was no significant difference in PAPP-A MoM (0.95, IQR 0.68-1.28 vs. 1.01, IQR 0.70-1.39) or uterine artery PI MoM (0.99, IQR 0.80-1.20 vs. 1.01, IQR 0.84-1.28). Conclusion: In pregnancies with isolated fetal heart defects there is evidence of impaired placental angiogenesis in the absence of impaired placental perfusion and function. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. |
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Authors:
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E Llurba; A Syngelaki; O Sánchez; E Carreras; L Cabero; Kh Nicolaides |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: - ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Department of Obstetrics, Maternal-Fetal Medicine Unit, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. Maternal and Child Health and Development Network (SAMID) RD 08/0072, Instituto de Salud Carlos III, Spain; Biochemistry and Molecular Biology Research Center for Nanomedicine, Vall Hebron University Hospital, Barcelona, Spain. Maternal and Child Health and Development Network (SAMID) RD 08/0072. Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain. ellurba@vhebron.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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