Document Detail

Maternal serum markers levels in consecutive pregnancies: a possible genetic predisposition to abnormal levels.
MedLine Citation:
PMID:  8669443     Owner:  NLM     Status:  MEDLINE    
The study comprised 2,361 women, each with two consecutive normal uncomplicated pregnancies screened at 15-20 weeks gestation for maternal serum alpha-fetoprotein levels (AFP). In 1,816 of these women, maternal serum human chorionic gonadotropin (hCG) levels were tested as well. The proportion of women who had a second high AFP level (> or = 2.0 MOM) in their subsequent pregnancy was 6.5-fold higher as compared with the proportion of women who had normal levels of AFP in their first tested pregnancy. The relative chance of having a second positive result of a low level of AFP (AFP < or = 0.5 MOM) in subsequent pregnancies was 3.8-fold higher. The relative chances of having a second positive result of high or low levels of hCG were 3.9- and 2.2-fold higher, respectively. It is concluded that there is a predisposition for abnormal levels of serum markers that is influenced by genetic and/or environmental factors. Therefore it is suggested that the individual's risk of having a Down syndrome baby, or other adverse pregnancy outcome that is derived from the serum markers' levels, should be adjusted taking into account unexplained high or low levels in previous pregnancies. A screening policy is suggested which is designed to yield a lower false-positive rate without affecting the detection rate of abnormal pregnancies. More data are needed before an accurate adjustment based on previous results can be made.
H Dar; R Merksamer; D Berdichevsky; M David
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of medical genetics     Volume:  61     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-08-05     Completed Date:  1996-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  154-7     Citation Subset:  IM    
Simon Winter Institute of Human Genetics, Bnai-Zion Medical Center, Haifa, Israel.
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MeSH Terms
Chorionic Gonadotropin / blood*
Down Syndrome / diagnosis*
Neural Tube Defects / diagnosis*
Pregnancy Outcome
Prenatal Diagnosis
Risk Factors
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins

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