| Maternal serum markers levels in consecutive pregnancies: a possible genetic predisposition to abnormal levels. | |
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MedLine Citation:
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PMID: 8669443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study comprised 2,361 women, each with two consecutive normal uncomplicated pregnancies screened at 15-20 weeks gestation for maternal serum alpha-fetoprotein levels (AFP). In 1,816 of these women, maternal serum human chorionic gonadotropin (hCG) levels were tested as well. The proportion of women who had a second high AFP level (> or = 2.0 MOM) in their subsequent pregnancy was 6.5-fold higher as compared with the proportion of women who had normal levels of AFP in their first tested pregnancy. The relative chance of having a second positive result of a low level of AFP (AFP < or = 0.5 MOM) in subsequent pregnancies was 3.8-fold higher. The relative chances of having a second positive result of high or low levels of hCG were 3.9- and 2.2-fold higher, respectively. It is concluded that there is a predisposition for abnormal levels of serum markers that is influenced by genetic and/or environmental factors. Therefore it is suggested that the individual's risk of having a Down syndrome baby, or other adverse pregnancy outcome that is derived from the serum markers' levels, should be adjusted taking into account unexplained high or low levels in previous pregnancies. A screening policy is suggested which is designed to yield a lower false-positive rate without affecting the detection rate of abnormal pregnancies. More data are needed before an accurate adjustment based on previous results can be made. |
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Authors:
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H Dar; R Merksamer; D Berdichevsky; M David |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of medical genetics Volume: 61 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-08-05 Completed Date: 1996-08-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 154-7 Citation Subset: IM |
Affiliation:
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Simon Winter Institute of Human Genetics, Bnai-Zion Medical Center, Haifa, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Gonadotropin
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blood* Down Syndrome / diagnosis* Female Humans Neural Tube Defects / diagnosis* Pregnancy Pregnancy Outcome Prenatal Diagnosis Risk Factors alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/alpha-Fetoproteins |
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