| Maternal serum markers in second-trimester oligohydramnios. | |
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MedLine Citation:
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PMID: 7526364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The levels of the maternal serum markers alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), and unconjugated oestriol (uE3) in 35 pregnant women with early second-trimester oligohydramnios differed from those in a reference population of 1699 singleton pregnancies. Maternal serum AFP levels above the 95th centile of the population distribution were observed in 80 per cent (16/20) of oligohydramnios cases with a normal fetus and in only 20 per cent (3/15) of the cases with a fetus displaying urogenital tract malformations. Elevated levels of hCG (above the 95th centile) and decreased levels of uE3 (below the fifth centile) were encountered in 26 per cent (9/35) and 17 per cent (6/35) of the women, irrespective of the fetal condition. The abnormal profile of the serum markers in early second-trimester oligohydramnios resulted in 57 per cent (20 out of 35) of screen-positive cases for either fetal Down's syndrome or neural tube defects, compared with 8.4 per cent (143 out of 1699) in the reference population. |
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Authors:
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F J Los; A M Hagenaars; T E Cohen-Overbeek; H W Quartero |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 14 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-12-16 Completed Date: 1994-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 565-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Genetics, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Gonadotropin
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blood* Congenital Abnormalities / ultrasonography Estriol / blood* Female Gestational Age* Humans Oligohydramnios / blood* Pregnancy Pregnancy Trimester, Second Reference Values Ultrasonography, Prenatal alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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