Document Detail

Maternal serum ischemia-modified albumin: a biomarker to distinguish between normal pregnancy and preeclampsia?
MedLine Citation:
PMID:  20132025     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether a biological marker of ischemia, ischemia-modified albumin (IMA), alone or normalized to albumin serum concentration, was modified during the course of pregnancy and so could be used for discrimination between normal pregnancy and preeclampsia.
METHODS: Serum IMA concentrations and IMA to serum albumin ratio (IMA/alb) were compared in 22 nonpregnant healthy women (NP), 19 healthy pregnant women (HP) and 20 pre-eclamptic women (PE). Influence of age of gestation on these markers was also investigated.
RESULTS: IMA to albumin ratio (IMA/alb) was significantly increased in HP compared with NP (IMA/alb. HP: 2.60 +/- 0.38 kU/g and IMA/alb. NP: 2.10 +/- 0.22 kU/g; p < 0.05). Both IMA and IMA/alb were significantly elevated during PE compared with HP (IMA HP: 98.4 +/- 9.2 kU/l and IMA PE 116.9 +/- 12.3 kU/l, p < 0.001; IMA/alb HP: 2.60 +/- 0.38 kU/g and IMA/alb PE: 3.79 +/- 0.75 kU/g p < 0.001)). Both IMA and IMA/alb were increased in PE up to delivery. No correlation could be demonstrated between gestational age and maternal IMA both in HP (r = 0.13; p = 0.071) or PE (r = 0.05; p = 0.318).
CONCLUSIONS: IMA and IMA normalized to albumin appear to be significantly increased during pathological pregnancies. These results confirm that IMA could be used as a biological marker of preeclampsia. These data need to be confirmed by determining intra-individual IMA change during normal and pathological pregnancy.
Benjamin Gafsou; Guillaume Lefèvre; Bernadette Hennache; Véronique Houfflin Debarge; Anne-Sophie Ducloy-Bouthors
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  29     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-05-03     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-11     Citation Subset:  IM    
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MeSH Terms
Biological Markers / metabolism
Chi-Square Distribution
Ischemia / metabolism*
Pre-Eclampsia / metabolism*
Serum Albumin / metabolism*
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Markers; 0/Serum Albumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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