| Maternal serum ischemia-modified albumin: a biomarker to distinguish between normal pregnancy and preeclampsia? | |
MedLine Citation:
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PMID: 20132025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether a biological marker of ischemia, ischemia-modified albumin (IMA), alone or normalized to albumin serum concentration, was modified during the course of pregnancy and so could be used for discrimination between normal pregnancy and preeclampsia. METHODS: Serum IMA concentrations and IMA to serum albumin ratio (IMA/alb) were compared in 22 nonpregnant healthy women (NP), 19 healthy pregnant women (HP) and 20 pre-eclamptic women (PE). Influence of age of gestation on these markers was also investigated. RESULTS: IMA to albumin ratio (IMA/alb) was significantly increased in HP compared with NP (IMA/alb. HP: 2.60 +/- 0.38 kU/g and IMA/alb. NP: 2.10 +/- 0.22 kU/g; p < 0.05). Both IMA and IMA/alb were significantly elevated during PE compared with HP (IMA HP: 98.4 +/- 9.2 kU/l and IMA PE 116.9 +/- 12.3 kU/l, p < 0.001; IMA/alb HP: 2.60 +/- 0.38 kU/g and IMA/alb PE: 3.79 +/- 0.75 kU/g p < 0.001)). Both IMA and IMA/alb were increased in PE up to delivery. No correlation could be demonstrated between gestational age and maternal IMA both in HP (r = 0.13; p = 0.071) or PE (r = 0.05; p = 0.318). CONCLUSIONS: IMA and IMA normalized to albumin appear to be significantly increased during pathological pregnancies. These results confirm that IMA could be used as a biological marker of preeclampsia. These data need to be confirmed by determining intra-individual IMA change during normal and pathological pregnancy. |
Authors:
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Benjamin Gafsou; Guillaume Lefèvre; Bernadette Hennache; Véronique Houfflin Debarge; Anne-Sophie Ducloy-Bouthors |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension in pregnancy Volume: 29 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-05-03 Revised Date: 2014-07-23 |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: England |
Other Details:
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Languages: eng Pagination: 101-11 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism Chi-Square Distribution Female Humans Ischemia / metabolism* Pre-Eclampsia / metabolism* Pregnancy Serum Albumin / metabolism* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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