| Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery. | |
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MedLine Citation:
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PMID: 10659917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the concentrations of maternal serum interleukins (ILs) 1, 2, 6, 8 and IL-2 receptors (IL-2R) in patients in their second and third trimesters of pregnancy and in preterm labor and delivery without evidence of chorioamnionitis. STUDY DESIGN: The study was conducted in La Paz Maternal Hospital, Madrid. Maternal serum IL concentrations were measured in 103 gravidas during preterm labor and delivery. The Mann-Whitney U test was used for analysis. RESULTS: Women in preterm labor and delivery had significantly higher median IL-2R concentration. Women who responded to tocolysis had significantly lower serum concentrations of IL-6. IL-2R and IL-6 serum concentrations predict delivery in 48 h and before 34 weeks gestation. CONCLUSIONS: Compared with non-laboring gravidas, those in idiopathic preterm labor or delivery had significantly higher concentrations of maternal serum IL-2R. Both IL-6 and IL-2R may predict failure of tocolysis. IL-2 does not seem to play an important role in pregnancy. |
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Authors:
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M Alvarez-de-la-Rosa; F J Rebollo; R Codoceo; A Gonzalez Gonzalez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 88 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-02-29 Completed Date: 2000-02-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 57-60 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, La Paz Hospital, Universidad Autónoma de Madrid, Spain. obgyn.fellows@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Delivery, Obstetric Female Humans Interleukin-1 / blood Interleukin-2 / blood Interleukin-6 / blood Interleukin-8 / blood Interleukins / blood* Obstetric Labor, Premature / blood*, drug therapy Predictive Value of Tests Pregnancy Pregnancy Trimester, Second / blood Pregnancy Trimester, Third / blood Receptors, Interleukin-2 / blood* Sensitivity and Specificity Tocolysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-6; 0/Interleukin-8; 0/Interleukins; 0/Receptors, Interleukin-2 |
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