Document Detail

Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery.
MedLine Citation:
PMID:  10659917     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the concentrations of maternal serum interleukins (ILs) 1, 2, 6, 8 and IL-2 receptors (IL-2R) in patients in their second and third trimesters of pregnancy and in preterm labor and delivery without evidence of chorioamnionitis. STUDY DESIGN: The study was conducted in La Paz Maternal Hospital, Madrid. Maternal serum IL concentrations were measured in 103 gravidas during preterm labor and delivery. The Mann-Whitney U test was used for analysis. RESULTS: Women in preterm labor and delivery had significantly higher median IL-2R concentration. Women who responded to tocolysis had significantly lower serum concentrations of IL-6. IL-2R and IL-6 serum concentrations predict delivery in 48 h and before 34 weeks gestation. CONCLUSIONS: Compared with non-laboring gravidas, those in idiopathic preterm labor or delivery had significantly higher concentrations of maternal serum IL-2R. Both IL-6 and IL-2R may predict failure of tocolysis. IL-2 does not seem to play an important role in pregnancy.
M Alvarez-de-la-Rosa; F J Rebollo; R Codoceo; A Gonzalez Gonzalez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  88     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-29     Completed Date:  2000-02-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
Department of Obstetrics and Gynecology, La Paz Hospital, Universidad Autónoma de Madrid, Spain.
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MeSH Terms
Biological Markers
Delivery, Obstetric
Interleukin-1 / blood
Interleukin-2 / blood
Interleukin-6 / blood
Interleukin-8 / blood
Interleukins / blood*
Obstetric Labor, Premature / blood*,  drug therapy
Predictive Value of Tests
Pregnancy Trimester, Second / blood
Pregnancy Trimester, Third / blood
Receptors, Interleukin-2 / blood*
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-6; 0/Interleukin-8; 0/Interleukins; 0/Receptors, Interleukin-2

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