Document Detail

Maternal serum inhibin A levels are a marker of a viable trophoblast in incomplete and complete miscarriage.
MedLine Citation:
PMID:  12590643     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: From early gestation the human trophoblast secretes large amounts of inhibin A and activin A, and their measurement provides a value for predicting the outcome in women who become pregnant after assisted reproductive techniques. The aim of the study was to investigate the putative role of maternal serum inhibin A and activin A levels as markers of a viable trophoblast in women who miscarry. DESIGN: Controlled cross-sectional study. METHODS: One group consisted of 65 healthy pregnant women (controls), progressing to deliver a healthy singleton baby and another group consisted of 54 miscarriages (38 incomplete (27 non-viable, 11 anembryonic pregnancies) and 16 complete). Maternal blood samples were collected between 5 and 12 weeks of gestation. RESULTS: Serum human chorionic gonadotrophin concentrations in women with incomplete or complete miscarriages were significantly (both P<0.001) lower than in controls; activin A levels being lowest only in women with a complete miscarriage (P<0.001). On the other hand, inhibin A levels were significantly lower in incomplete or complete miscarriage than in controls (both P<0.0001). CONCLUSIONS: Maternal serum inhibin A, but not activin A, determination reflects the lack of a viable trophoblast in complete miscarriage.
S Luisi; P Florio; D D'Antona; F M Severi; F Sanseverino; S Danero; F Petraglia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  148     ISSN:  0804-4643     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-19     Completed Date:  2003-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  IM    
Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
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MeSH Terms
Abortion, Spontaneous / blood*,  physiopathology*
Activins / blood
Chorionic Gonadotropin / blood
Cross-Sectional Studies
Inhibin-beta Subunits / blood
Inhibins / blood*
Pregnancy / blood*
Trophoblasts / physiology*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/activin A; 0/inhibin A; 104625-48-1/Activins; 57285-09-3/Inhibins; 93443-12-0/Inhibin-beta Subunits

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