| Maternal serum inhibin A levels are a marker of a viable trophoblast in incomplete and complete miscarriage. | |
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MedLine Citation:
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PMID: 12590643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: From early gestation the human trophoblast secretes large amounts of inhibin A and activin A, and their measurement provides a value for predicting the outcome in women who become pregnant after assisted reproductive techniques. The aim of the study was to investigate the putative role of maternal serum inhibin A and activin A levels as markers of a viable trophoblast in women who miscarry. DESIGN: Controlled cross-sectional study. METHODS: One group consisted of 65 healthy pregnant women (controls), progressing to deliver a healthy singleton baby and another group consisted of 54 miscarriages (38 incomplete (27 non-viable, 11 anembryonic pregnancies) and 16 complete). Maternal blood samples were collected between 5 and 12 weeks of gestation. RESULTS: Serum human chorionic gonadotrophin concentrations in women with incomplete or complete miscarriages were significantly (both P<0.001) lower than in controls; activin A levels being lowest only in women with a complete miscarriage (P<0.001). On the other hand, inhibin A levels were significantly lower in incomplete or complete miscarriage than in controls (both P<0.0001). CONCLUSIONS: Maternal serum inhibin A, but not activin A, determination reflects the lack of a viable trophoblast in complete miscarriage. |
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Authors:
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S Luisi; P Florio; D D'Antona; F M Severi; F Sanseverino; S Danero; F Petraglia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 148 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-19 Completed Date: 2003-04-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 233-6 Citation Subset: IM |
Affiliation:
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Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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blood*,
physiopathology* Activins / blood Chorionic Gonadotropin / blood Cross-Sectional Studies Female Humans Inhibin-beta Subunits / blood Inhibins / blood* Pregnancy / blood* Trophoblasts / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/activin A; 0/inhibin A; 104625-48-1/Activins; 57285-09-3/Inhibins; 93443-12-0/Inhibin-beta Subunits |
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