Document Detail

Maternal serum inhibin A can predict pre-eclampsia.
MedLine Citation:
PMID:  9800934     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare median levels of maternal serum inhibin A in the second trimester blood samples of women who subsequently develop pre-eclampsia and those who do not. DESIGN: Retrospective analysis of 13 18 week samples from a bank of serum stored at -40 degrees C, originally taken for Down's syndrome screening. SETTING: Antenatal clinics in a teaching hospital. SAMPLE: Twenty-eight pregnancies with pre-eclampsia and 701 controls. Samples were taken, on average, 22 weeks before the diagnosis. MAIN OUTCOME MEASURE: Median inhibin A level. RESULTS: The median inhibin A level in the cases was 2.01 multiples of the gestation-specific median in the controls, a statistically significant elevation (P < 0.001). Twenty-three (82%) had levels above the normal median; 19 (68%), 15 (54%), and 11 (39%) exceeded the normal 75th, 90th and 95th centiles, respectively. CONCLUSIONS: In pre-eclampsia the maternal serum inhibin A level can be increased months before the onset of symptoms. This provides an opportunity to study the early natural history of the disease and possibly to conduct treatment trials.
H Cuckle; I Sehmi; R Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  105     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-10     Completed Date:  1998-11-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1101-3     Citation Subset:  AIM; IM    
Centre for Reproduction, Growth and Development, University of Leeds, UK.
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MeSH Terms
Biological Markers / blood
Inhibins / blood*
Pre-Eclampsia / blood,  diagnosis*
Pregnancy Trimester, Second
Prenatal Diagnosis / methods
Retrospective Studies
Reg. No./Substance:
0/Biological Markers; 57285-09-3/Inhibins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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