Document Detail


Maternal serum human chorionic gonadotrophin levels in systemic lupus erythematosus and antiphospholipid syndrome.
MedLine Citation:
PMID:  11241544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal serum human chorionic gonadotrophin (hCG) levels were measured during the second and the third trimesters of pregnancy in patients with either systemic lupus erythematosus (SLE) or primary antiphospholipid syndrome (APS). All results were expressed in multiples of the gestation-specific normal medians (MoM). The median MoM level in 17 samples from SLE patients was 1.48 compared with 0.79 MoM in 99 controls of similar gestation (p < 0.002, Wilcoxon Rank sum test). In contrast the median MoM level in 19 samples from primary APS patients was only 1.14. These preliminary findings should be further studied to evaluate the implications for Down syndrome screening, detection of SLE cases during pregnancy and the prediction of adverse outcome in SLE gestations.
Authors:
R Maymon; H Cuckle; I K Sehmi; A Herman; D Sherman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  21     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-5     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Ltd.
Affiliation:
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin 70300, Israel.
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MeSH Terms
Descriptor/Qualifier:
Antiphospholipid Syndrome / blood*
Chorionic Gonadotropin / blood*
Down Syndrome / diagnosis
False Positive Reactions
Female
Gestational Age
Humans
Lupus Coagulation Inhibitor / blood
Lupus Erythematosus, Systemic / blood*
Pregnancy
Pregnancy Complications / blood*,  immunology
Prenatal Diagnosis
Regression Analysis
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Lupus Coagulation Inhibitor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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