| Maternal serum hepcidin is low at term and independent of cord blood iron status. | |
| | |
MedLine Citation:
|
PMID: 20528904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Hepcidin is the key regulator of iron homeostasis. The aims of this study were to determine serum hepcidin concentrations and reference ranges in pregnant women and cord blood of newborns at term and to evaluate the associations between hepcidin concentrations and iron status parameters. METHODS: A total of 191 pregnant women-newborn pairs were studied in Kuopio University Hospital, Finland. The measured parameters were serum hepcidin, ferritin, transferrin receptor, transferrin saturation, red cell indices, and erythropoietin. RESULTS: The hepcidin concentration in pregnant women was significantly lower than in cord blood at term [geometric mean concentration (GMC) (95% confidence intervals) in pregnant women 10.7 ng/mL (8.5-13.4 ng/mL) vs. GMC of cord blood hepcidin 69.3 ng/mL (55.3-86.8 ng/mL), P<0.001, adjusted analysis of variance]. Hepcidin was undetectable in 12% of mothers. Hepcidin concentration in pregnant women was the lowest in those who had the lowest iron status. However, maternal hepcidin concentration was not associated with cord blood hepcidin or iron status markers. Hepcidin concentration in cord blood was associated with cord blood iron status, but not with maternal iron status. CONCLUSIONS: At term pregnancy, hepcidin concentrations are very low, allowing maximal availability of iron for the fetus. Maternal and cord blood hepcidin levels were independently associated with either maternal or cord blood iron status. |
| | |
Authors:
|
Mari Rehu; Kari Punnonen; Vaughn Ostland; Seppo Heinonen; Mark Westerman; Kari Pulkki; Ulla Sankilampi |
Related Documents
:
|
1578534 - Spinal cord injury in experimental thoracic aortic occlusion: investigation of combined... 12610744 - Transplacental passage of lamotrigine in a human placental perfusion system in vitro an... 11252134 - The role of the dorsal column pathway in visceral nociception. 11304964 - Factors affecting the volume of umbilical cord blood collections. 15278474 - The effect of vagal afferent on total vascular compliance in rats. 3487264 - The effect of regional lung injury or alveolar hypoxia on pulmonary blood flow and lung... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-22 |
Journal Detail:
|
Title: European journal of haematology Volume: 85 ISSN: 1600-0609 ISO Abbreviation: Eur. J. Haematol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-21 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: England |
Other Details:
|
Languages: eng Pagination: 345-52 Citation Subset: IM |
Copyright Information:
|
© 2010 John Wiley & Sons A/S. |
Affiliation:
|
Department of Clinical Chemistry, University of Eastern Finland, Eastern Finland Laboratory Centre (ISLAB), Kuopio, Finland. mari.ervasti@uef.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antimicrobial Cationic Peptides
/
blood* Enzyme-Linked Immunosorbent Assay Female Ferritins / blood Fetal Blood / chemistry* Humans Infant, Newborn / blood* Iron / blood* Maternal-Fetal Exchange Pregnancy / blood* Reference Values |
| Chemical | |
Reg. No./Substance:
|
0/Antimicrobial Cationic Peptides; 0/hepcidin; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of free immunoglobulin light chains in cerebrospinal fluids of patients with central nervo...
Next Document: CLINICAL SIGNIFICANCE OF OCCULT CEREBROSPINAL FLUID INVOLVEMENT ASSESSED BY FLOW CYTOMETRY IN NON HO...