Document Detail

Maternal serum hCG, PAPP-A and AFP as predictors of hemoglobin Bart disease at mid-pregnancy.
MedLine Citation:
PMID:  21312197     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the ability of maternal serum-free β-human chorionic gonadotrophin (β-hCG), pregnancy-associated plasma protein-A (PAPP-A), and alpha fetoprotein (AFP) levels in the screening of fetuses with hemoglobin (Hb) Bart's disease among pregnancies at risk.
MATERIALS AND METHODS: Pregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22 weeks were recruited into the study. Maternal serum-free β-hCG, PAPP-A, and AFP concentrations were measured before cordocentesis, and the final fetal diagnosis of Hb Bart disease was based on fetal Hb typing using high-performance liquid chromatography.
RESULTS: Of 57 recruited pregnancies, 11 had fetal Hb Bart's disease and 46 were unaffected. Maternal serum alpha-fetoprotein (MSAFP) concentrations were significantly higher in women with fetal Hb Bart's disease than those with unaffected fetuses (median 99.53 vs 50.83, P < 0.001), whereas the concentrations of free β-hCG and PAPP-A were not significantly different between the two groups (P = 0.543 and 0.777, respectively).
CONCLUSION: Second-trimester MSAFP may be clinically a useful screening test for fetal Hb Bart's disease among pregnancies at risk.
Fuanglada Tongprasert; Chanane Wanapirak; Theera Tongsong
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Publication Detail:
Type:  Journal Article     Date:  2011-02-10
Journal Detail:
Title:  Prenatal diagnosis     Volume:  31     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-09-22     Revised Date:  2013-07-23    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  430-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
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MeSH Terms
Chorionic Gonadotropin / blood*
Gestational Age
Hemoglobinopathies / blood,  diagnosis*,  embryology
Hemoglobins, Abnormal / analysis
Predictive Value of Tests
Pregnancy Complications
Pregnancy Trimester, Second
Pregnancy-Associated Plasma Protein-A / metabolism*
Prospective Studies
alpha-Fetoproteins / metabolism*
Reg. No./Substance:
0/AFP protein, human; 0/Chorionic Gonadotropin; 0/Hemoglobins, Abnormal; 0/alpha-Fetoproteins; 9056-09-1/hemoglobin Bart's; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A
Comment In:
Prenat Diagn. 2011 Sep;31(9):920-1   [PMID:  23737152 ]

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