Document Detail

Maternal serum granulocyte colony-stimulating factor levels and spontaneous preterm birth.
MedLine Citation:
PMID:  19105692     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Preterm birth (PTB) remains a cause of substantial morbidity with an elusive etiology. Previous studies suggested an association of PTB with elevated serum levels of granulocyte colony-stimulating factor (G-CSF) at 28 weeks gestation. G-CSF, a hematopoietic cytokine, mediates the increase in leukocytes in pregnancy and may play a role in placentation. We evaluated the association between maternal serum G-CSF in the first and second trimesters and PTB.
METHODS: Serum samples collected for the Collaborative Perinatal Project (CPP) from women with normal pregnancy (n = 394) and PTB (n = 31), defined as delivery before 37 weeks gestation, were used to assess G-CSF levels. Linear regression was used to evaluate the relation of G-CSF with gestational age (GA) at birth. Logistic regression, conditional on GA at sample provision, was used to model the association between G-CSF and PTB.
RESULTS: G-CSF was significantly associated with gestational age at birth (p = 0.02). In conditional logistic regression models, G-CSF was significantly associated with PTB, with an adjusted odds ratio (AOR) of 1.52 (95% confidence interval [CI] 1.07, 2.16) per standard deviation (SD) increase.
CONCLUSIONS: Acute effects of G-CSF on PTB have been suggested. In our study we observed an association of higher serum G-CSF levels early in the second trimester with PTB, suggesting PTB as the culmination process beginning early in, if not before, pregnancy.
Brian W Whitcomb; Enrique F Schisterman; Xiaoping Luo; Nasser Chegini
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Journal of women's health (2002)     Volume:  18     ISSN:  1931-843X     ISO Abbreviation:  J Womens Health (Larchmt)     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-04-27     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  101159262     Medline TA:  J Womens Health (Larchmt)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
Epidemiology Branch, DESPR, NICHD, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland.
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MeSH Terms
Biological Markers / blood
Birth Weight
Delivery, Obstetric
Enzyme-Linked Immunosorbent Assay
Gestational Age*
Granulocyte Colony-Stimulating Factor / blood*
Infant, Newborn
Infant, Premature / physiology
Logistic Models
Obstetric Labor, Premature / blood*,  diagnosis
Pregnancy / blood*
Pregnancy Trimester, Second / blood*
Premature Birth / blood*,  diagnosis
Time Factors
Young Adult
Grant Support
Z01 HD008762-05/HD/NICHD NIH HHS
Reg. No./Substance:
0/Biological Markers; 143011-72-7/Granulocyte Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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