| Maternal serum granulocyte colony-stimulating factor levels and spontaneous preterm birth. | |
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MedLine Citation:
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PMID: 19105692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Preterm birth (PTB) remains a cause of substantial morbidity with an elusive etiology. Previous studies suggested an association of PTB with elevated serum levels of granulocyte colony-stimulating factor (G-CSF) at 28 weeks gestation. G-CSF, a hematopoietic cytokine, mediates the increase in leukocytes in pregnancy and may play a role in placentation. We evaluated the association between maternal serum G-CSF in the first and second trimesters and PTB. METHODS: Serum samples collected for the Collaborative Perinatal Project (CPP) from women with normal pregnancy (n = 394) and PTB (n = 31), defined as delivery before 37 weeks gestation, were used to assess G-CSF levels. Linear regression was used to evaluate the relation of G-CSF with gestational age (GA) at birth. Logistic regression, conditional on GA at sample provision, was used to model the association between G-CSF and PTB. RESULTS: G-CSF was significantly associated with gestational age at birth (p = 0.02). In conditional logistic regression models, G-CSF was significantly associated with PTB, with an adjusted odds ratio (AOR) of 1.52 (95% confidence interval [CI] 1.07, 2.16) per standard deviation (SD) increase. CONCLUSIONS: Acute effects of G-CSF on PTB have been suggested. In our study we observed an association of higher serum G-CSF levels early in the second trimester with PTB, suggesting PTB as the culmination process beginning early in, if not before, pregnancy. |
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Authors:
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Brian W Whitcomb; Enrique F Schisterman; Xiaoping Luo; Nasser Chegini |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Journal of women's health (2002) Volume: 18 ISSN: 1931-843X ISO Abbreviation: J Womens Health (Larchmt) Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-01-09 Completed Date: 2009-04-27 Revised Date: 2010-09-29 |
Medline Journal Info:
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Nlm Unique ID: 101159262 Medline TA: J Womens Health (Larchmt) Country: United States |
Other Details:
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Languages: eng Pagination: 73-8 Citation Subset: IM |
Affiliation:
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Epidemiology Branch, DESPR, NICHD, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland. bwhitcomb@schoolph.umass.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biological Markers / blood Birth Weight Delivery, Obstetric Enzyme-Linked Immunosorbent Assay Female Gestational Age* Granulocyte Colony-Stimulating Factor / blood* Humans Infant, Newborn Infant, Premature / physiology Logistic Models Obstetric Labor, Premature / blood*, diagnosis Pregnancy / blood* Pregnancy Trimester, Second / blood* Premature Birth / blood*, diagnosis Serum Time Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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Z01 HD008762-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 143011-72-7/Granulocyte Colony-Stimulating Factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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