Document Detail

Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring.
MedLine Citation:
PMID:  21324652     Owner:  NLM     Status:  MEDLINE    
It is believed that during mid-to-late gestation, docosahexaenoic acid (DHA), an n-3 fatty acid, plays an important role in fetal and infant brain development, including neurocognitive and neuromotor functions. Deficits in several such functions have been associated with schizophrenia. Though sufficient levels of DHA appear to be important in neurodevelopment, elevated maternal DHA levels have also been associated with abnormal reproductive outcomes in both animal models and humans. Our objective was to assess whether a disturbance in maternal DHA levels, measured prospectively during pregnancy, was associated with risk of schizophrenia and other schizophrenia spectrum disorders (SSD) in adult offspring. In order to test the hypothesis that abnormal levels of DHA are associated with SSD, a case-control study nested within a large, population-based birth cohort, born from 1959 through 1967 and followed up for SSD from 1981 through 1997, was utilized. Maternal levels of both DHA and arachidonic acid (AA), an n-6 fatty acid, were analyzed in archived maternal sera from 57 cases of SSD and 95 matched controls. There was a greater than twofold increased risk of SSD among subjects exposed to maternal serum DHA in the highest tertile (OR=2.38, 95% CI=1.19, 4.76, p=0.01); no such relationship was found between AA and SSD. These findings suggest that elevated maternal DHA is associated with increased risk for the development of SSD in offspring.
Kristin N Harper; Joseph R Hibbeln; Richard Deckelbaum; Charles P Quesenberry; Catherine A Schaefer; Alan S Brown
Publication Detail:
Type:  Journal Article     Date:  2011-02-15
Journal Detail:
Title:  Schizophrenia research     Volume:  128     ISSN:  1573-2509     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-24     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  30-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Adult Children*
Analysis of Variance
Case-Control Studies
Chi-Square Distribution
Child of Impaired Parents
Cohort Studies
Docosahexaenoic Acids / blood*
Middle Aged
Prenatal Exposure Delayed Effects*
Psychotic Disorders / blood*
Risk Factors
Schizophrenia / blood*
Schizophrenia, Paranoid / blood*
Young Adult
Grant Support
K02 MH065422/MH/NIMH NIH HHS; K02 MH065422-01A2/MH/NIMH NIH HHS; R01 HL040404/HL/NHLBI NIH HHS; R01 HL040404-12/HL/NHLBI NIH HHS
Reg. No./Substance:
25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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