Document Detail

Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy.
MedLine Citation:
PMID:  12620429     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare serum cytokine levels in patients with hyperemesis gravidarum with levels in healthy pregnant and nonpregnant women. DESIGN: Case-control study. SETTING: Clinical and academic research center. PATIENT(S): Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy nonpregnant women. MAIN OUTCOME MEASURE(S): Serum levels of interleukin-1beta, interleukin-2 receptor, interleukin-6, interleukin-8, and tumor necrosis factor (TNF)-alpha. RESULT(S): Median serum levels of interleukin-2 receptor and interleukin-8 did not differ significantly among the three groups. Serum levels of interleukin-1beta and interleukin-6 were significantly higher in healthy pregnant women than in healthy nonpregnant women. Median TNF-alpha levels were significantly higher in women with hyperemesis (25.8 pg/mL [range, 4.9-140 pg/mL]) than in healthy pregnant and nonpregnant women (10.85 pg/mL [range, 4.1-35.8 pg/mL] and 12 pg/mL [4.3-68.2 pg/mL], respectively). CONCLUSION(S): Levels of TNF-alpha were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women. Thus, TNF-alpha may be involved in the etiology of hyperemesis gravidarum.
Petek Balkanli Kaplan; Fatih Gücer; N Cenk Sayin; Mahmut Yüksel; M Ali Yüce; Turgut Yardim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  79     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-06     Completed Date:  2003-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  498-502     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine, Trakya University, Edirne, Turkey.
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MeSH Terms
Cytokines / blood*
Hyperemesis Gravidarum / blood*
Interleukin-1 / blood
Interleukin-6 / blood
Interleukin-8 / blood
Pregnancy Trimester, First
Receptors, Interleukin-2 / blood
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Cytokines; 0/Interleukin-1; 0/Interleukin-6; 0/Interleukin-8; 0/Receptors, Interleukin-2; 0/Tumor Necrosis Factor-alpha

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