Document Detail


Maternal serum cholesterol levels are elevated from the 1st trimester of pregnancy: A cross-sectional study.
MedLine Citation:
PMID:  23075347     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cholesterol is monitored in the non-pregnant adult population, where normal values are established. Although reported to be elevated in pregnancy, cholesterol is neither routinely measured nor treated. We aimed to investigate cholesterol levels throughout pregnancy and to establish reference values for cholesterol in healthy pregnant women. This was a cross-sectional analysis of serum cholesterol in healthy women with an uncomplicated singleton pregnancy. Pregnant women attending for antenatal care were recruited and cholesterol levels assayed at 12, 20, 28 and 36 weeks' gestation and on day 1-3 postpartum. A total of 222 women were recruited. The majority (95%) were white Irish, with a median age of 31 years (range 16-46). Median BMI was 25.9 kg/m(2) (range 18-40) and 16% were smokers. Cholesterol levels were elevated in all trimesters of pregnancy, with median values from 1st trimester raised outside the non-pregnant adult range. High-density lipoprotein (HDL) levels ranged from 0.9 to 3.7 mmol/l and low-density lipoprotein (LDL) levels ranged from 1.3 to 6.1 mmol/l. Fasting, smoking and obesity did not have any significant effects on results. Total and LDL-cholesterol levels were raised throughout pregnancy. Levels were above non-pregnant adult ranges as early as the 1st trimester. The implications of this on fetus and mother are undetermined and deserve further investigation.
Authors:
A Bartels; N Egan; D I Broadhurst; A S Khashan; C Joyce; M Stapleton; J O'Mullane; K O'Donoghue
Related Documents :
1685367 - Nutritional implications for nitrogen and mineral budgets from analysis of guano of the...
1333097 - Serum osteocalcin as a marker for vitamin k-status in pregnant women and their newborn ...
526487 - Contents of trace elements in the human liver before birth.
9474827 - Factors affecting the use of folic acid supplements in pregnant women in glasgow.
1239217 - The effect of lumbar epidural anesthesia on fetal heart rate baseline variability.
14652157 - Effect of antenatal exposure to maternal smoking on behavioural problems and academic a...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  32     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  747-52     Citation Subset:  IM    
Affiliation:
Anu Research Centre, Department of Obstetrics and Gynaecology , University College Cork, Cork University Maternity Hospital, Cork , Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Venous thromboprophylaxis in pregnancy: The implications of changing to the 2010 RCOG guidelines.
Next Document:  Methadone use in pregnancy: Evidence of progression in the severity of addiction.