Document Detail

Maternal serum activin A levels in association with intrauterine fetal growth restriction.
MedLine Citation:
PMID:  12628273     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess maternal serum activin A as a potential marker of fetal growth restriction. DESIGN: A cohort study. SETTING: A maternal-fetal medicine unit, university teaching hospital. POPULATION: Fifty-seven women with a small fetus (less than 10th centile for gestation) referred for assessment of fetal size by ultrasound biometry. METHODS: At the time of presentation for fetal biometry, maternal blood was collected for activin A measurement. The case records of each woman were independently reviewed after delivery and the pregnancy grouped into one of three groups: constitutionally small fetus, intrauterine growth restricted (IUGR) fetus or IUGR fetus and maternal pre-eclampsia (IUGR-pre-eclampsia). Activin A levels in the three groups were compared. MAIN OUTCOME MEASURES: Maternal serum activin A levels. RESULTS: Sixteen of the 57 pregnancies were classified as constitutionally small, 17 as IUGR and 24 as IUGR-pre-eclampsia. Expressed as multiples of a normal median (MoMs), the median (95% CI) activin A level in the constitutionally small pregnancies was 1.12 (0.72-1.39) MoMs significantly lower than the level in both the IUGR pregnancies, 3.00 (1.84-4.11) MoMs, and the IUGR-pre-eclampsia pregnancies, 7.96 (5.73-10.62) MoMs (P = 0.002 and 0.0001 for IUGR vs constitutionally small and IUGR-pre-eclampsia vs constitutionally small, respectively). CONCLUSIONS: Maternal serum activin A may be useful in the assessment of the small for gestational age fetus.
Euan M Wallace; Michal E Schneider-Kolsky; Andrew Edwards; Lesleigh Baker; Graham Jenkin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  110     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-11     Completed Date:  2003-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Victoria, Clayton, Australia.
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MeSH Terms
Activins / blood*
Biological Markers / blood
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Fetal Growth Retardation / blood,  diagnosis*,  etiology
Infant, Newborn
Infant, Small for Gestational Age / growth & development
Inhibin-beta Subunits / blood*
Pre-Eclampsia / blood,  complications*
Reg. No./Substance:
0/Biological Markers; 0/activin A; 104625-48-1/Activins; 93443-12-0/Inhibin-beta Subunits

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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