Document Detail

Maternal serum ADAM12 in Chinese women undergoing screening for aneuploidy in the first trimester.
MedLine Citation:
PMID:  20230315     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the potential of maternal serum using a disintegrin and metalloprotease 12 (ADAM12) as a marker for Trisomy 21 in Chinese pregnant women.
METHODS: Serum samples were collected and stored from women having a viable singleton pregnancy undergoing first trimester screening for Trisomy 21 between 2006 and 2007. Serum concentration of ADAM12 was measured using an automated time-solved immuno-fluorometric assay from 608 stored serum samples (601 Euploidy and 7 Trisomy 21). Regression analysis was used to determine the expected median in Euploidy pregnancies after adjusting for pregnancy characteristics. The level of ADAM12 MoM was compared between Trisomy 21 and Euploidy pregnancies. Expected median levels in Chinese were compared to that published for Caucasians and Afro-Caribbeans.
RESULTS: In Euploidy pregnancies, the concentration of ADAM12 increased with CRL and decreased with maternal weight. The expected median level of ADAM12 in Chinese was significantly lower than Caucasian and Afro-Caribbeans (F=14.2, p<0.0001). There was a significant correlation between log10ADAM12 MoM both log10 pregnancy-associated plasma protein A MoMs (r=0.46; p<0.001) and log10free βhCG MoMs (r=0.08; p=0.048). The median ADAM12 MoM in Trisomy 21 pregnancies was not significantly different from that in Euploidy pregnancies (z=0.18; p=0.88).
CONCLUSION: ADAM12 concentrations in Chinese are lower than those of Caucasians and Afro-Carribeans; that ADAM12 MoM levels in Euploidy and Trisomy 21 pregnancies were not statistically different.
Can Liao; Jin Han; Daljit Sahota; Dong-zhi Li; Qian Sun; Lin Lin; Jian-ying Zhou; Xin Yang; Min Pan; Yi-ning Huang
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1305-9     Citation Subset:  IM    
Prenatal Diagnostic Center, Guangzhou Women and Children Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China.
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MeSH Terms
ADAM Proteins / blood*
Asian Continental Ancestry Group*
Case-Control Studies
Down Syndrome / blood,  diagnosis*
Mass Screening / methods
Membrane Proteins / blood*
Pregnancy Trimester, First / blood*,  physiology
Prenatal Diagnosis / methods
Young Adult
Reg. No./Substance:
0/Membrane Proteins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins

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