Document Detail

Maternal separation enhances object location memory and prevents exercise-induced MAPK/ERK signalling in adult Sprague-Dawley rats.
MedLine Citation:
PMID:  22476924     Owner:  NLM     Status:  MEDLINE    
Early life stress increases the risk of developing psychopathology accompanied by reduced cognitive function in later life. Maternal separation induces anxiety-like behaviours and is associated with impaired memory. On the other hand, exercise has been shown to diminish anxiety-like behaviours and improve cognitive function. The effects of maternal separation and exercise on anxiety, memory and hippocampal proteins were investigated in male Sprague-Dawley rats. Maternal separation produced anxiety-like behaviours which were reversed by exercise. Maternal separation also enhanced object location memory which was not affected by exercise. Exercise did, however, increase synaptophysin and phospho-extracellular signal-regulated kinase (p-ERK) in the hippocampus of non-separated rats and this effect was not observed in maternally separated rats. These findings show that maternal separation selectively enhanced n memory and prevented activation of the MAPK/ERK signalling pathway in the adult rat hippocampus.
Nokuthula Makena; Kishor Bugarith; Vivienne A Russell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-03
Journal Detail:
Title:  Metabolic brain disease     Volume:  27     ISSN:  1573-7365     ISO Abbreviation:  Metab Brain Dis     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-24     Completed Date:  2013-05-24     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-85     Citation Subset:  IM    
Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa.
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MeSH Terms
Age Factors
Animals, Newborn
Disease Models, Animal
Hippocampus / growth & development,  metabolism*
MAP Kinase Signaling System / physiology*
Maternal Deprivation*
Memory / physiology*
Physical Conditioning, Animal / physiology*
Rats, Sprague-Dawley
Stress, Psychological / metabolism,  physiopathology*
Grant Support

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