| Maternal selenium nutrition and neonatal immune system development. | |
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MedLine Citation:
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PMID: 12169835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the impact of dietary selenium intake on neonatal immune cell differentiation and function. A low selenium intake during pregnancy and lactation produced reductions in maternal plasma selenium (33%, p = 0.0001), milk selenium (36%, p = 0.001), and corresponding neonatal plasma selenium (47%, p = 0.008). Thymocytes from neonates receiving low-selenium milk showed an impaired activation in vitro (p = 0.001). The percentages of CD8 cytotoxic T cells (p = 0.03), CD2 T cells (p = 0.09), panB cells ( = 0.02), and natural killer cells (p = 0.07) were all decreased in neonates nursed by mothers fed a low-selenium diet. The results indicate that maternal selenium intake impacts neonatal selenium status which in turn influences the neonatal immune system development. |
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Authors:
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Maggie L Dylewski; Andrea M Mastro; Mary Francis Picciano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology of the neonate Volume: 82 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-09 Completed Date: 2003-03-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 122-7 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Department of Nutrition, Pennsylvania State University, University Park, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / immunology* Anthropometry Cell Differentiation Cell Division Diet Female Immune System / growth & development* Lymphocytes / cytology Maternal Nutritional Physiological Phenomena* Pregnancy Pregnancy, Animal / physiology* Rats Rats, Sprague-Dawley Selenium* / administration & dosage |
| Chemical | |
Reg. No./Substance:
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7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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