Document Detail

Maternal selenium levels and sudden infant death syndrome (SIDS).
MedLine Citation:
PMID:  8958364     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The possibility is tested that low anti-oxidant status and/or low levels of selenium (Se) might predispose to Sudden Infant Death Syndrome (SIDS). AIM: This study was undertaken to collect evidence on the Se status of pregnant and non-pregnant women and newborn babies and to establish whether babies who later died of cot death had significantly divergent levels of blood Se at birth. METHODOLOGY: Aliquots of blood were collected from all newly pregnant mothers in Tasmania and from the cords of all newborn babies. These were analysed for Se and glutathione peroxidase (GPx) content and compared by season and with non-pregnant, age standardised blood donors in three areas of Tasmania and three mainland Australian States. RESULTS: Cot death babies' cordbloods were not significantly different in Se or GPx-status, in this small sample, from those of other babies, nor was a seasonal variation in these parameters demonstrated among 390 randomly selected Tasmanian mothers. Mothers-to-be showed a decrease in enzyme levels during pregnancy and Tasmanian blood donors had significantly lower levels than donors from other States. CONCLUSION: While no evidence can safely be drawn about a relationship between Se or GPx-status and SIDS, this study provides base level measures for populations showing that Tasmanian residents have low levels of these anti-oxidants.
N D McGlashan; S J Cook; W Melrose; P L Martin; E Chelkowska; R J von Witt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  26     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-03-25     Completed Date:  1997-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  677-82     Citation Subset:  IM    
Department of Geography and Environmental Studies, University of Tasmania, Hobart.
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MeSH Terms
Australia / epidemiology
Blood Donors
Fetal Blood / chemistry
Glutathione Peroxidase / blood
Infant, Newborn
Pregnancy / blood*
Random Allocation
Selenium / blood*
Sudden Infant Death / epidemiology,  etiology*
Reg. No./Substance:
7782-49-2/Selenium; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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