Document Detail

Maternal salivary cortisol differs by fetal sex during the second half of pregnancy.
MedLine Citation:
PMID:  20940089     Owner:  NLM     Status:  MEDLINE    
Maternal salivary cortisol was measured at weekly intervals from 24 to 38 weeks gestation. The total sample consisted of 120 women enrolled in staggered intervals in such a way as to generate weekly measures of salivary cortisol during the latter half of pregnancy. Hierarchical linear modeling revealed the expected increase in unbound maternal cortisol during this period, with a slight deceleration in rate of increase at 33 weeks gestation. Women carrying male fetuses had higher levels of salivary cortisol initially as compared to women carrying female fetuses; at 30 weeks gestation there was cross-over such that higher maternal cortisol was observed in women carrying female fetuses beyond this time and through term. Results highlight the importance of considering fetal sex as a moderator of contemporaneous and predictive associations between maternal cortisol and prenatal or postnatal development.
Janet A DiPietro; Kathleen A Costigan; Katie T Kivlighan; Ping Chen; Mark L Laudenslager
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  36     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-03-04     Completed Date:  2011-06-22     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  588-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Population, Family & Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., W1033, Baltimore, MD 21205, USA.
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MeSH Terms
Cohort Studies
Fetus / physiology*
Gestational Age
Hydrocortisone / analysis,  metabolism*
Longitudinal Studies
Pregnancy / metabolism
Pregnancy Trimester, Second / metabolism*,  physiology
Pregnancy Trimester, Third / metabolism*,  physiology
Saliva / chemistry,  metabolism*
Sex Characteristics*
Grant Support
R01 HD027592-20/HD/NICHD NIH HHS; R01 HD27592/HD/NICHD NIH HHS; R56 HD027592-17/HD/NICHD NIH HHS
Reg. No./Substance:

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