| Maternal risk factors in cleft lip and palate: case control study. | |
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MedLine Citation:
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PMID: 10783443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three hundred and six mothers who gave birth to babies with cleft lip, or palate, or both, were matched with 306 who gave birth to healthy babies in the same area during the same time period. Significantly more babies in the cleft group had a family history of clefts (48/306 compared with 7/306, P<0.0001). In the cases studied, combined cleft lip and palate was significantly more common among boys (82/157 compared with 57/149, P=0.02) and cleft palate alone among girls (48/149 compared with 22/157, P=0.0002). Significantly more mothers reported some sort of illness during early pregnancy (101/306 compared with 74/306, P=0.02). There were no differences between the groups as far as dietary preferences were concerned but during early pregnancy the mothers who gave birth to babies with defects tended to drink less alcohol (<1 unit/week) (236 compared with 199, P=0.001) and less coffee (<1 cup/week) (159/306 compared with 131, P=0.03). However, in each case similar proportions gave up once the pregnancy was confirmed. Large multicentre studies are required to confirm or refute these findings. |
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Authors:
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N Natsume; T Kawai; N Ogi; W Yoshida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of oral & maxillofacial surgery Volume: 38 ISSN: 0266-4356 ISO Abbreviation: Br J Oral Maxillofac Surg Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-06-09 Completed Date: 2000-06-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8405235 Medline TA: Br J Oral Maxillofac Surg Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 23-5 Citation Subset: D; IM |
Affiliation:
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The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking Case-Control Studies Cleft Lip / epidemiology, etiology*, genetics Cleft Palate / epidemiology, etiology*, genetics Coffee Diet Family Health Female Food Preferences Humans Infant, Newborn Japan / epidemiology Male Pregnancy Prenatal Exposure Delayed Effects Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Coffee |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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