Document Detail

Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia.
MedLine Citation:
PMID:  22321195     Owner:  NLM     Status:  MEDLINE    
Prenatal hypoxia is a common complication in pregnancy. We sought to determine whether resveratrol, a phytoalexin shown to improve health in several species, improves fetal outcomes associated with prenatal hypoxia in rats. Supplementation of maternal diets with resveratrol (4 g/kg diet) from gestational day (GD) 7 to GD21 almost completely reversed fetal demise in hypoxic (8.5% oxygen) pregnancies. We also show that resveratrol crosses the placenta, and may affect the fetus directly.
S L Bourque; V W Dolinsky; J R B Dyck; S T Davidge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-10
Journal Detail:
Title:  Placenta     Volume:  33     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-08-03     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  449-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Antioxidants / therapeutic use*
Drug Evaluation, Preclinical
Fetal Hypoxia / drug therapy*
Pregnancy Outcome
Stilbenes / therapeutic use*
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Antioxidants; 0/Stilbenes; Q369O8926L/resveratrol

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