| Maternal respiratory sensitization and gestational allergen exposure does not affect subsequent pup responses to homologous or heterologous allergen. | |
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MedLine Citation:
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PMID: 19916739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence suggests that the predisposition towards atopy begins early in life. Maternal allergy has been associated with an increased risk of the development of allergic disease in offspring. Some studies suggest that the development of childhood atopy may also be influenced by prenatal allergen exposure. In this study, a respiratory allergen exposure model was used to determine the impact of maternal sensitization (with or without additional exposures during pregnancy) on subsequent pup responses to homologous or heterologous allergen. Female BALB/c mice received two intratracheal aspiration (IA) exposures to Metarhizium anisopliae crude antigen (MACA) or Hank's buffered salt solution (HBSS) prior to breeding. Some mice also received three additional exposures during pregnancy. Control mothers did not receive treatment. Young adult offspring received three IA exposures to MACA, house dust mite extract (HDM) or HBSS. Offspring sensitized as young adults to either HDM or MACA developed an airway inflammatory response, including increased bronchoalveolar lavage fluid lactate dehydrogenase activity, total protein and total and differential cell counts compared to offspring exposed to HBSS. Increased airway responsiveness to methacholine was observed in pups treated with HDM but not with MACA. Maternal sensitization status (with or without gestational allergen exposure) had no effect on offspring response to either MACA or HDM. In conclusion, this study demonstrates that IA administration of MACA or HDM extract to young adult BALB/c mice induces the development of an inflammatory airway response. In contrast to previous reports, neither maternal sensitization nor gestational allergen exposure could be demonstrated to have a clear effect on offspring sensitization. This discrepancy may be a function of the respiratory sensitization and exposure protocol used in this study, which mimics natural sensitization more closely than do parenteral routes of exposure. |
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Authors:
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Cherie M Pucheu-Haston; Lisa B Copeland; Najwa Haykal-Coates; Marsha D W Ward |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of immunotoxicology Volume: 7 ISSN: 1547-6901 ISO Abbreviation: J Immunotoxicol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101201960 Medline TA: J Immunotoxicol Country: England |
Other Details:
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Languages: eng Pagination: 57-67 Citation Subset: IM |
Affiliation:
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Curriculum in Toxicology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27711, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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administration & dosage,
immunology* Animals Antigens, Fungal / administration & dosage, immunology Bronchial Hyperreactivity / immunology*, pathology, physiopathology Bronchoalveolar Lavage Fluid / chemistry, cytology Female Intubation, Intratracheal Male Maternal Exposure / adverse effects* Maternal-Fetal Exchange Methacholine Chloride / diagnostic use Mice Mice, Inbred BALB C Mitosporic Fungi / immunology Pregnancy Pregnancy Complications / immunology* Pregnancy Outcome Prenatal Exposure Delayed Effects* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antigens, Fungal; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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