Document Detail


Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant.
MedLine Citation:
PMID:  23083673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Probiotics have shown promising potential in reducing the risk of eczema in infants. Optimal probiotic intervention regimen remains to be determined.
OBJECTIVE: We investigated whether maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of developing eczema in high-risk infants.
METHODS: This was a parallel, double-blind placebo-controlled trial of 241 mother-infant pairs. Mothers with allergic disease and atopic sensitization were randomly assigned to receive (1) Lactobacillus rhamnosus LPR and Bifidobacterium longum BL999 (LPR+BL999), (2) L paracasei ST11 and B longum BL999 (ST11+BL999), or (3) placebo, beginning 2 months before delivery and during the first 2 months of breast-feeding. The infants were followed until the age of 24 months. Skin prick tests were performed at the ages of 6, 12, and 24 months.
RESULTS: Altogether 205 infants completed the follow-up and were included in the analyses. The risk of developing eczema during the first 24 months of life was significantly reduced in infants of mothers receiving LPR+BL999 (odds ratio [OR], 0.17; 95% CI, 0.08-0.35; P < .001) and ST11+BL999 (OR, 0.16; 95% CI, 0.08-0.35; P < .001). The respective ORs for chronically persistent eczema were 0.30 (95% CI, 0.12-0.80; P = .016) and 0.17 (95% CI, 0.05-0.56; P = .003). Probiotics had no effect on the risk of atopic sensitization in the infants. No adverse effects were related to the use of probiotics.
CONCLUSION: Prevention regimen with specific probiotics administered to the pregnant and breast-feeding mother, that is, prenatally and postnatally, is safe and effective in reducing the risk of eczema in infants with allergic mothers positive for skin prick test.
Authors:
Samuli Rautava; Essi Kainonen; Seppo Salminen; Erika Isolauri
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-10-16
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  130     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-02-28     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1355-60     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Paediatrics, Turku University Central Hospital, Turku, Finland. samrau@utu.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Breast Feeding
Dietary Supplements*
Eczema / immunology,  prevention & control*
Female
Follow-Up Studies
Humans
Immunoglobulin E / blood
Infant, Newborn
Male
Maternal Exposure
Pregnancy
Probiotics / administration & dosage*
Risk
Skin Tests
Young Adult
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E
Comments/Corrections
Comment In:
J Allergy Clin Immunol. 2013 May;131(5):1447-8   [PMID:  23538235 ]
J Allergy Clin Immunol. 2013 May;131(5):1447   [PMID:  23538236 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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