Document Detail

Maternal prenatal cigarette, alcohol and illicit drug use and risk of infant leukaemia: a report from the Children's Oncology Group.
MedLine Citation:
PMID:  21980945     Owner:  NLM     Status:  MEDLINE    
Several case-control studies have evaluated associations between maternal smoking, alcohol consumption and illicit drug use during pregnancy and risk of childhood leukaemia. Few studies have specifically focused on infants (<1 year) with leukaemia, a group that is biologically and clinically distinct from older children. We present data from a Children's Oncology Group case-control study of 443 infants diagnosed with acute leukaemia [including acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML)] between 1996 and 2006 and 324 population controls. Mothers were queried about their cigarette, alcohol and illicit drug use 1 year before and throughout pregnancy. Odds ratios (ORs) and 95% confidence intervals [CI] were calculated using adjusted unconditional logistic regression models. Maternal smoking (>1 cigarette/day) and illicit drug use (any amount) before and/or during pregnancy were not significantly associated with infant leukaemia. Alcohol use (>1 drink/week) during pregnancy was inversely associated with infant leukaemia overall [OR = 0.64; 95% CI 0.43, 0.94], AML [OR = 0.49; 95% CI 0.28, 0.87], and leukaemia with mixed lineage leukaemia gene rearrangements ('MLL+') [OR = 0.59; 95% CI 0.36, 0.97]. While our results agree with the fairly consistent evidence that maternal cigarette smoking is not associated with childhood leukaemia, the data regarding alcohol and illicit drug use are not consistent with prior reports and are difficult to interpret. It is possible that unhealthy maternal behaviours during pregnancy, some of which carry potential legal consequences, may not be adequately measured using only self-report. Future case-control studies of childhood leukaemia that pursue these exposures may benefit from incorporation of validated instruments and/or biomarkers when feasible.
Megan E Slater; Amy M Linabery; Cindy K Blair; Logan G Spector; Nyla A Heerema; Leslie L Robison; Julie A Ross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-08-10
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  25     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-10     Completed Date:  2012-01-31     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  559-65     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, 55455, USA.
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MeSH Terms
Alcohol Drinking / adverse effects*
Case-Control Studies
Infant, Newborn
Leukemia / epidemiology*,  etiology
Logistic Models
Maternal Welfare
Prenatal Exposure Delayed Effects / epidemiology*,  etiology
Risk Factors
Smoking / adverse effects*
Street Drugs / adverse effects*
Time Factors
Grant Support
P30 CA077598/CA/NCI NIH HHS; P30 CA77598/CA/NCI NIH HHS; R01 CA079940/CA/NCI NIH HHS; R01 CA79940/CA/NCI NIH HHS; T32 CA099936/CA/NCI NIH HHS; T32 CA99936/CA/NCI NIH HHS; U10 CA013539/CA/NCI NIH HHS; U10 CA098413/CA/NCI NIH HHS; U10 CA098543/CA/NCI NIH HHS; U10 CA13539/CA/NCI NIH HHS; U10 CA98413/CA/NCI NIH HHS; U10 CA98543/CA/NCI NIH HHS
Reg. No./Substance:
0/Street Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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