Document Detail

Maternal pregnancy vomiting and offspring salt taste sensitivity and blood pressure.
MedLine Citation:
PMID:  15864654     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the relationship between salt taste perception and blood pressure (BP) in normotensive adolescents as modified by maternal fluid losses during the first trimester of gestation. Seventy-two healthy adolescents (42 boys) aged between 9.0-21.1 years, recruited from the population-based RICARDIN study, were included. A maternal questionnaire about the duration of pregnancy, birth weight and vomiting or diarrhoea in the first trimester of gestation was collected. The sample was categorized into: "vomiter descendents", those whose mother reported significant vomiting in the first trimester of gestation and "non-vomiter descendents" the remaining. Height, weight, and standardised BP measurement were recorded. Salt gustatory performance was assessed using a behavioral sensitivity test to determine the lower NaCl gustatory threshold, and a behavioral discrimination test, measuring the ability to distinguish among different saline solutions. Salt taste sensitivity showed a significant correlation with systolic BP (SBP) in "vomiter descendents" ( r = -0.66; P =0.003), but not in "non-vomiter descendents". Adjusted by gender, and actual height and weight, salt sensitivity performance remained significantly related to SBP. An association between descendents' SBP and maternal vomiting during gestation exists, adding a new element of evidence to the "Barker hypothesis".
Ignacio Málaga; Juan Arguelles; Juan José Díaz; Carmen Perillán; Manuel Vijande; Serafín Málaga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-27
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  20     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-16     Completed Date:  2005-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  956-60     Citation Subset:  IM    
Section of Pediatric Nephrology, Department of Pediatrics, Hospital Universitario Central de Asturias, University of Oviedo, C/ Celestino Villamil s/n., 33007 Oviedo, Spain.
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MeSH Terms
Blood Pressure*
Body Weight
Case-Control Studies
Pregnancy Complications / physiopathology*
Regression Analysis
Severity of Illness Index
Sodium Chloride*
Taste Threshold*
Vomiting / physiopathology*
Reg. No./Substance:
7647-14-5/Sodium Chloride

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