Document Detail

Maternal pregnancy-related hypertension and risk for hypertension in offspring later in life.
MedLine Citation:
PMID:  20859149     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the association between maternal pregnancy-related hypertension and offspring hypertension later in life in a birth cohort from New England.
METHODS: Covariate and exposure data were collected between 1959 and 1966 through the Collaborative Perinatal Project. Follow-up information was obtained through the New England Family Study between 2001 and 2004, when study participants were between 34 and 44 years old. The study population consisted of 1,556 individuals. Participants who reported having hypertension diagnosed at least once were considered to have hypertension. Logistic regression was used to estimate the association between maternal pregnancy-related hypertension and offspring hypertension later in life. Results were adjusted for sex, maternal race, maternal body mass index, maternal socioeconomic status, maternal diabetes, and twin pregnancy.
RESULTS: Maternal pregnancy-related hypertension was associated with an increased risk of being prescribed antihypertensives compared with never having hypertension diagnosed (from 8.8% to 17.4%; adjusted odds ratio 1.88, 95% confidence interval 1.00-3.55). The association was not attenuated after adjustment for birth weight or preterm delivery. After excluding offspring of women who reported hypertension during pregnancy only, this association increased to an adjusted odds ratio of 1.97 (95% confidence interval 1.04-3.72).
CONCLUSION: In a birth cohort from New England, maternal pregnancy-related hypertension was associated with hypertension in offspring later in life.
Kristin Palmsten; Stephen L Buka; Karin B Michels
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  116     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-10-22     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  858-64     Citation Subset:  AIM; IM    
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
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MeSH Terms
Confounding Factors (Epidemiology)
Hypertension / epidemiology*
Hypertension, Pregnancy-Induced / epidemiology*
Logistic Models
New England / epidemiology
Pre-Eclampsia / epidemiology
Prenatal Exposure Delayed Effects / epidemiology*
Risk Assessment
Risk Factors
Young Adult
Grant Support
AG023397/AG/NIA NIH HHS; P50 CA084719/CA/NCI NIH HHS; P50 CA084719/CA/NCI NIH HHS; R01 AG023397/AG/NIA NIH HHS

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