Document Detail

Maternal pregnancy events and exposures and risk of hepatoblastoma: a Children's Oncology Group (COG) study.
MedLine Citation:
PMID:  23312454     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring.
METHODS: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls.
RESULTS: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR = 1.02; 95% CI 1.00, 1.04 per 1 lb increase and nearly significantly with maternal multivitamin use (OR = 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy.
CONCLUSION: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring.
Jessica R B Musselman; Michael K Georgieff; Julie A Ross; Gail E Tomlinson; James Feusner; Mark Krailo; Logan G Spector
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Publication Detail:
Type:  Journal Article     Date:  2013-01-09
Journal Detail:
Title:  Cancer epidemiology     Volume:  37     ISSN:  1877-783X     ISO Abbreviation:  Cancer Epidemiol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-15     Completed Date:  2013-11-06     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101508793     Medline TA:  Cancer Epidemiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  318-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Case-Control Studies
Child, Preschool
Hepatoblastoma / epidemiology*,  etiology
Infant, Newborn
Liver Neoplasms / epidemiology*,  etiology
Pregnancy Complications / epidemiology*
Risk Factors
United States / epidemiology
Grant Support
K05 CA157439/CA/NCI NIH HHS; R01 CA111355/CA/NCI NIH HHS; T32 CA099936/CA/NCI NIH HHS; U10 CA098543/CA/NCI NIH HHS

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