Document Detail


Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study.
MedLine Citation:
PMID:  23312454     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR=1.02; 95% CI 1.00, 1.04 per 1lb increase and nearly significantly with maternal multivitamin use (OR=0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring.
Authors:
Jessica R B Musselman; Michael K Georgieff; Julie A Ross; Gail E Tomlinson; James Feusner; Mark Krailo; Logan G Spector
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  Cancer epidemiology     Volume:  -     ISSN:  1877-783X     ISO Abbreviation:  Cancer Epidemiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101508793     Medline TA:  Cancer Epidemiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pediatrics, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, United States.
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