Document Detail

Maternal plasma prostaglandin E2 metabolite levels during human pregnancy and parturition.
MedLine Citation:
PMID:  3857076     Owner:  NLM     Status:  MEDLINE    
Because of methodological problems associated with the measurement in biological fluids of both prostaglandin E2 (PGE2) and its unstable principal circulating metabolite 13,14-dihydro-15-keto-PGE2 (PGEM), there is little reliable information on these prostaglandins in human pregnancy and parturition. The recent discovery of a stable PGEM degradation product 11-deoxy-13,14-dihydro-15-keto-11 beta, 16 epsilon-cyclo-PGE2 (bicyclo-PGEM) has provided a means of studying endogenous plasma levels of PGEM which circumvents the problems encountered with direct measurements of PGE2 and PGEM. Using a radioimmunoassay for bicyclo-PGEM we have therefore determined maternal peripheral plasma PGE2 metabolite levels during human gestation. PGE2 metabolite levels did not alter significantly during the second or third trimesters nor during labour. This contrasts with maternal peripheral plasma levels of the principal circulating metabolite of PGF2 alpha 13,14-dihydro-15-keto-PGF2 alpha (PGFM) which increases several fold during labour. Compared to PGE2 therefore, PGF2 alpha may be quantitatively the more significant prostaglandin associated with human parturition.
S P Brennecke; B M Castle; L M Demers; A C Turnbull
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  92     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-06-17     Completed Date:  1985-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  345-9     Citation Subset:  AIM; IM    
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MeSH Terms
Labor, Obstetric*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prostaglandins E / blood*
Reg. No./Substance:
0/Prostaglandins E; 363-23-5/15-keto-13,14-dihydroprostaglandin E2; 363-24-6/Dinoprostone; 74158-09-1/11-deoxy-15-keto-13,14-dihydro-11 beta,16-cycloprostaglandin E2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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