Document Detail


Maternal plasma polychlorinated biphenyl levels in cynomolgus monkeys (Macaca fascicularis) affect infant social skills in mother-infant interaction.
MedLine Citation:
PMID:  20945409     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Polychlorinated biphenyls (PCBs) are endocrine disrupting chemicals that disturb normal development of embryonic brains. In the present study, we evaluated the relationship between maternal plasma PCB concentration and infant behavioral characteristics in mother-infant interactions. We grouped 20 pregnant cynomolgus monkeys (Macaca fascicularis) into higher and lower PCB exposure groups; monkeys in the higher PCB group had PCB concentrations above 15 pg/g, which is representative of natural exposure levels. Maternal PCB concentration correlated negatively with infant behaviors (approach, look, proximity, locomotion) at the age of 6 months (p < .05), when an increase in these behaviors should normally occur. These results suggest that maternal PCB exposure may affect the development of infant social behavior in cynomolgus monkeys. Furthermore, this study provides primate evidence to support observations of associations between behavioral and learning disabilities and prenatal exposure to PCBs in humans.
Authors:
Akiko Nakagami; Takamasa Koyama; Katsuyoshi Kawasaki; Takayuki Negishi; Toshio Ihara; Yoichiro Kuroda; Yasuhiro Yoshikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental psychobiology     Volume:  53     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-88     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc. Dev Psychobiol 53: 79-88, 2011.
Affiliation:
Department of Psychology, Japan Women's University, 1-1-1 Nishi-ikuta, Tama-ku Kawasaki-shi, Kanagawa, Japan. anakagami@fc.jwu.ac.jp
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