Document Detail

Maternal plasma and placental immunoreactive corticotrophin-releasing factor concentrations in infection-associated term and pre-term delivery.
MedLine Citation:
PMID:  7792279     Owner:  NLM     Status:  MEDLINE    
The present study aimed to investigate whether microbial invasion of the amniotic cavity affects maternal plasma or placental immunoreactive corticotrophin releasing factor (ir-CRF) concentrations in pregnant women with pre-term or term labour. A cross-sectional study was conducted collecting blood samples in: (1) women with pre-term labour and intact membranes (25-36 weeks), with or without microbial invasion of the amniotic cavity (subdivided into three groups: 1A, no microbial invasion of the amniotic cavity, delivery at term, n = 54; group 1B, delivery < 48 h, no microbial invasion of the amniotic cavity, n = 10; group 1C, delivery < 48 h, microbial invasion of the amniotic cavity, n = 8); (2) women at term, not in labour and without microbial invasion of the amniotic cavity (n = 15); (3) women in spontaneous active labour at term without (A) (n = 55) or with (B) (n = 16) microbial invasion of the amniotic cavity; and (4) healthy women not in labour at 25-36 weeks of gestation (n = 25). Specimens of trophoblast tissue were collected from pregnant women with pre-term labour (no microbial invasion of the amniotic cavity, n = 6; microbial invasion of the amniotic cavity, n = 4) or delivering at term (no microbial invasion of the amniotic cavity, n = 8; microbial invasion of the amniotic cavity, n = 4). A specific radioimmunoassay on acidic extracts of plasma or placental specimens was used.(ABSTRACT TRUNCATED AT 250 WORDS)
F Petraglia; L Aguzzoli; P Florio; P Baumann; A D Genazzani; C Di Carlo; R Romero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  16     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-24     Completed Date:  1995-07-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Modena School of Medicine, Italy.
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MeSH Terms
Amnion / microbiology
Corticotropin-Releasing Hormone / analysis*,  blood
Cross-Sectional Studies
Maternal-Fetal Exchange*
Obstetric Labor Complications / blood,  metabolism*
Obstetric Labor, Premature / blood,  metabolism*
Placenta / chemistry*
Pregnancy Complications, Infectious / blood,  metabolism*
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone

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