Document Detail

Maternal plasma pentraxin 3 at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy.
MedLine Citation:
PMID:  19565609     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether in pregnancies that subsequently develop preeclampsia (PE), the maternal plasma concentration of the inflammatory factor pentraxin 3 (PTX3) at 11-13 weeks of gestation is increased and whether such a possible increase is associated with uterine artery pulsatility index (PI). METHODS: The concentration of plasma PTX3 at 11-13 weeks was measured in a case-control study from 120 pregnancies that developed PE, including 27 who required delivery before 34 weeks (early PE), 87 cases of gestational hypertension (GH) and 207 normal controls. The median PTX3 multiple of the median (MoM) in the control and hypertensive groups were compared. Regression analysis was used to determine the significance of the association between plasma PTX3 and uterine artery PI. RESULTS: Plasma PTX3 was significantly higher in the early PE group (1.44 MoM; p < 0.0083) but not in late PE (1.11 MoM) or GH (1.10 MoM) compared to the controls (0.97 MoM). There was no significant association between plasma PTX3 levels and uterine artery PI in either the PE group (p = 0.693) or in the controls (p = 0.209). CONCLUSION: Increase in maternal plasma PTX3 in pregnancies that subsequently develop early PE is evident from 11-13 weeks but the underlying mechanism for such an increase remains uncertain.
Ranjit Akolekar; Davide Casagrandi; Panagiotis Livanos; Amos Tetteh; Kypros H Nicolaides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  29     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  934-8     Citation Subset:  IM    
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
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MeSH Terms
C-Reactive Protein / analysis*
Case-Control Studies
Cohort Studies
Hypertension, Pregnancy-Induced / blood*,  diagnosis
Pregnancy Trimester, First / blood*
Pulsatile Flow / physiology
Serum Amyloid P-Component / analysis*
Uterine Artery / physiology
Reg. No./Substance:
0/Serum Amyloid P-Component; 148591-49-5/PTX3 protein; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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