Document Detail

Maternal plasma homocysteine levels in women with preterm premature rupture of membranes.
MedLine Citation:
PMID:  11133260     Owner:  NLM     Status:  MEDLINE    
Homocysteine is a sulfur-containing amino acid produced by the breakdown of methionine. Plasma homocysteine levels can be elevated due to a variety of genetic and nutritional factors. Poor nutrition from diets low in folate and vitamin B12 can lead to hyperhomocysteinemia. Mildly elevated levels of homocysteine have been implicated in a number of disease processes such as atherosclerotic vascular disease and adverse obstetrical outcomes. High levels of plasma homocysteine are also associated with abnormal collagen cross-linking. Due to homocysteine's effects on connective tissue integrity, it is hypothesized that hyperhomocysteinemia in pregnancy is associated with preterm premature rupture of membranes (PPROM). Hyperhomocysteinemia, therefore, could be a treatable cause of this important public health concern.
S E Ferguson; G N Smith; M C Walker
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  56     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Amino Acid Metabolism, Inborn Errors / complications
Collagen / metabolism
Fetal Membranes, Premature Rupture / blood*,  etiology
Homocysteine / blood*
Reg. No./Substance:
454-28-4/Homocysteine; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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