| Maternal plasma D-dimer levels in normal and complicated pregnancies. | |
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MedLine Citation:
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PMID: 8423957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate D-dimer as a marker for fibrinolysis in normal and complicated pregnancies using an enzyme-linked immunosorbent assay (ELISA) technique. METHODS: Four groups of pregnant women were enrolled: 17 normal women followed longitudinally from 28-40 weeks' gestation, 14 patients with preterm labor at 28-34 weeks, 17 patients with preeclampsia at term (37-40 weeks), and 14 patients with abruptio placentae (32-40 weeks). We assayed peripheral venous blood samples from each patient for D-dimer levels using a commercial ELISA kit. D-dimer values were calculated by regression analysis using internal standards and controls for each assay. Data were compared using Student t test or analysis of variance with repeated measures. RESULTS: D-dimer values increased slightly with increasing gestational age. Patients with preterm labor, preeclampsia, and abruptio placentae had mean D-dimer values significantly greater than those of controls (P < .003). D-dimer values of the abruption group were approximately twice those of the control group (3393 +/- 2086 versus 1750 +/- 839 ng/dL). CONCLUSION: An increase in fibrinolysis may be associated with the pregnancy complications studied, as reflected by alterations in maternal plasma D-dimer levels. |
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Authors:
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T E Nolan; R P Smith; L D Devoe |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 81 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-02-22 Completed Date: 1993-02-22 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 235-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abruptio Placentae
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blood* Adult Biological Markers / blood Enzyme-Linked Immunosorbent Assay Female Fibrin Fibrinogen Degradation Products / analysis* Fibrinolysis Humans Obstetric Labor, Premature / blood* Pre-Eclampsia / blood* Pregnancy / blood* Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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