| Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development. | |
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MedLine Citation:
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PMID: 20803692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As background for an antibody-based therapeutic program against the IGF receptor, we undertook a review of available information on the early pregnancy-specific regulation and localization of IGFs, IGF-binding proteins (BPs), IGFBP-specific proteases, and the type 1 IGF receptor relative to placental maintenance, function of placental nutrient transporters, placental cellular differentiation/turnover/apoptosis, and critical hormone signaling needed to maintain pregnancy. Possible adverse outcomes of altered IGF signaling include prenatal loss, fetal growth retardation, and maldevelopment are also discussed. It appears that the IGF axes in both the conceptus and mother are important for normal embryo-fetal growth. Thus, all molecules (i.e., both small and large) that disrupt the IGF axis could be expected to have some degree of fetal consequences. |
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Authors:
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Christopher J Bowman; Randal D Streck; Robert E Chapin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Birth defects research. Part B, Developmental and reproductive toxicology Volume: 89 ISSN: 1542-9741 ISO Abbreviation: Birth Defects Res. B Dev. Reprod. Toxicol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155115 Medline TA: Birth Defects Res B Dev Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 339-49 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley-Liss, Inc. |
Affiliation:
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Drug Safety Research and Development, Pfizer, Inc, Groton, Connecticut 06340, USA. christopher.j.bowman@pfizer.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryonic Development* Female Fetal Development* Fetal Growth Retardation / metabolism Humans Maternal-Fetal Exchange Placenta / embryology*, metabolism Pregnancy Pregnancy Complications / metabolism Somatomedins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Somatomedins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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