Document Detail

Maternal pinealectomy increases depressive-like responses in Siberian hamster offspring.
MedLine Citation:
PMID:  18328579     Owner:  NLM     Status:  MEDLINE    
This study investigated the effect of maternal pinealectomy and postnatal pinealectomy on affective responses. Siberian hamsters were born to either pinealectomized or sham-operated dams and then underwent pinealectomy or a sham operation. Maternal pinealectomy increased depressive-like responses of offspring in the forced swim test. Maternal pinealectomy increased rearing behaviour and postnatal pinealectomy increased locomotor behaviour in the open field test. These results suggest that prenatal melatonin organizes adult affective responses.
Joanna L Workman; Zachary M Weil; Christiana R Tuthill; Randy J Nelson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-02-05
Journal Detail:
Title:  Behavioural brain research     Volume:  189     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  387-91     Citation Subset:  IM    
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA.
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MeSH Terms
Anxiety / physiopathology*
Circadian Rhythm / physiology
Depression / physiopathology*
Exploratory Behavior / physiology
Maternal Behavior / physiology*
Motor Activity / physiology
Pineal Gland / physiology*,  surgery
Prenatal Exposure Delayed Effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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