Document Detail

Maternal, perinatal, and postneonatal outcomes in women with chronic heart disease in Washington State.
MedLine Citation:
PMID:  23168751     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the association between the presence of maternal heart disease and maternal, perinatal, and infant outcomes.
METHODS: We conducted a population-based retrospective cohort study using Washington State birth certificates linked with hospital discharge records of mothers noted to have maternal congenital heart disease, ischemic heart disease, heart failure, or pulmonary hypertension. Women who gave birth between 1987 and 2009 (n=2,171) were compared with a sample of mothers without these conditions (n=21,710). We described characteristics of pregnant women with heart disease over time. Logistic regression estimated the association between chronic maternal heart disease and small-for-gestational-age (SGA) neonates as well as perinatal, postneonatal, and maternal death.
RESULTS: The proportion of births to women with reported heart disease increased 224% between the 1987 and 1994 and 2002 and 2009 calendar periods. Chronic maternal heart disease was associated with increased risk of SGA (62 additional SGA newborns per 1,000 births, 95% confidence interval [CI] 46-78; P<.001), perinatal death (14 additional deaths per 1,000 births, 95% CI 8-20; P<.001), postneonatal death (5 additional deaths per 1,000 births, 95% CI 2-9; P<.001), and maternal death (5 additional deaths per 1,000 births, 95% CI 2-9; P<.001).
CONCLUSION: The presence of chronic maternal heart disease is associated with elevated risk for poor maternal, perinatal, and postneonatal outcomes.
Peter J Leary; Sarah E S Leary; Karen K Stout; Stephen M Schwartz; Thomas R Easterling
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  120     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-21     Completed Date:  2013-02-08     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1283-90     Citation Subset:  AIM; IM    
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MeSH Terms
Chronic Disease
Fetal Mortality*
Heart Diseases / congenital,  epidemiology*
Hypertension, Pulmonary / congenital,  epidemiology
Infant Mortality*
Infant, Newborn
Infant, Small for Gestational Age
Maternal Mortality
Maternal Welfare
Retrospective Studies
Washington / epidemiology
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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