Document Detail

Maternal and perinatal brain aromatase: effects of dietary soy phytoestrogens.
MedLine Citation:
PMID:  11248356     Owner:  NLM     Status:  MEDLINE    
Phytoestrogens are extensively investigated for their potential to prevent many hormone-dependent cancers and age-related diseases, however little is known about their effects in brain. Brain aromatase and plasma phytoestrogen levels were determined in Sprague-Dawley rats fed a phytoestrogen-rich diet during pregnancy/lactation. Ingested phytoestrogens cross the placenta and become concentrated in maternal milk as evident from high infantile plasma concentrations. Dietary phytoestrogens, however, do not alter brain aromatase during pregnancy/lactation or perinatal development.
K S Weber; K D Setchell; E D Lephart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  126     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
633 WIDB, Neuroscience Center, Brigham Young University, Provo, UT 84602, USA.
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MeSH Terms
Animals, Newborn
Aromatase / metabolism*
Body Weight / drug effects
Brain / embryology,  enzymology*
Enzyme Activation / drug effects
Estrogens, Non-Steroidal / blood,  pharmacology*
Food, Formulated
Hypothalamus, Middle / embryology,  enzymology
Isoflavones / blood
Maternal-Fetal Exchange
Plant Preparations
Prenatal Exposure Delayed Effects
Preoptic Area / embryology,  enzymology
Rats, Sprague-Dawley
Sex Factors
Reg. No./Substance:
0/Estrogens, Non-Steroidal; 0/Isoflavones; 0/Phytoestrogens; 0/Plant Preparations; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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