Document Detail

Maternal overweight and pregnancy outcome in women with Type-1 diabetes mellitus and different degrees of nephropathy.
MedLine Citation:
PMID:  20059444     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We aimed to assess the parameters associated with complicated pregnancy in women with Type 1 diabetes mellitus (DM) and nephropathy.
STUDY DESIGN: A cohort study of 46 consecutive women diagnosed with Type 1 DM with nephropathy prior to pregnancy was included during the years 2000-2007. Complicated pregnancy was defined as one or more of the following: first trimester abortion, superimposed pre-eclampsia, pre-term delivery <34 weeks, small and large for gestational age neonate, macrosomia, admission to the neonatal intensive care unit and foetal loss (after 22 weeks' gestation).
RESULTS: Overall, 31/46 (67%) had at least one pregnancy complication. Body mass index (BMI) was the only parameter with a significant difference between the groups, being higher in the women with complicated pregnancy vs. uncomplicated pregnancy (27 +/- 9 vs. 24 +/- 3, p = 0.027). On Multiple logistic regression model in which composite outcome (pregnancy complication) as the dependent variable, pre-pregnancy BMI was the only statistically significant parameter with a difference between the groups (p = 0.044). No statistical difference was found between the groups in the rate of pre-pregnancy counselling (60% vs. 67%), glycaemic control prior to pregnancy (Hba1c 7.5 vs. 7.1%), the prevalence of patients achieving desired level of glycaemic control (44% vs. 42%), weight gain during pregnancy (12.4 vs. 10.6 kg), duration of DM (18.0 vs. 19.7 years) and proportion of patients treated with angiotensin converting enzyme inhibitors prior to pregnancy (26 vs. 33%).
CONCLUSION: Overweight is associated with poor pregnancy outcome in patients with Type-1 DM and different degrees of nephropathy.
Yariv Yogev; Rony Chen; Avi Ben-Haroush; Moshe Hod; Jacob Bar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  999-1003     Citation Subset:  IM    
Perinatal Division, Helen Schneider Hospital for Women, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Petah-Tiqva, Israel.
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MeSH Terms
Birth Weight
Body Mass Index
Cohort Studies
Diabetes Mellitus, Type 1 / complications,  epidemiology*
Diabetic Nephropathies / complications,  epidemiology*,  pathology
Infant, Newborn
Infant, Newborn, Diseases / epidemiology,  etiology
Intensive Care Units, Neonatal / utilization
Maternal-Fetal Exchange / physiology
Overweight / complications,  epidemiology*
Patient Admission / statistics & numerical data
Pregnancy Complications / epidemiology,  pathology
Pregnancy Outcome / epidemiology*
Pregnancy in Diabetics / epidemiology*
Retrospective Studies
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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