Document Detail


Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts.
MedLine Citation:
PMID:  22447643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Though toxicological experiments demonstrate the teratogenicity of organic solvents in animal models, epidemiologic studies have reported inconsistent results. Using data from the population-based National Birth Defects Prevention Study, the authors examined the relation between maternal occupational exposure to aromatic solvents, chlorinated solvents and Stoddard solvent during early pregnancy and neural tube defects (NTDs) and orofacial clefts (OFCs).
METHODS: Cases of NTDs (anencephaly, spina bifida and encephalocoele) and OFCs (cleft lip ± cleft palate and cleft palate alone) delivered between 1997 and 2002 were identified by birth defect surveillance registries in eight states; non-malformed control infants were selected using birth certificates or hospital records. Maternal solvent exposure was estimated by industrial hygienist review of self-reported occupational histories in combination with a literature-derived exposure database. ORs and 95% CIs for the association between solvent class and each birth defect group and component phenotype were estimated using multivariable logistic regression, adjusting for maternal age, race/ethnicity, education, pre-pregnancy body mass index, folic acid supplement use and smoking.
RESULTS: The prevalence of exposure to any solvent among mothers of NTD cases (n = 511), OFC cases (n = 1163) and controls (n = 2977) was 13.1%, 9.6% and 8.2%, respectively. Exposure to chlorinated solvents was associated with increased odds of NTDs (OR = 1.96, CI 1.34 to 2.87), especially spina bifida (OR = 2.26, CI 1.44 to 3.53). No solvent class was strongly associated with OFCs in these data.
CONCLUSIONS: The findings suggest that maternal occupational exposure to chlorinated solvents during early pregnancy is positively associated with the prevalence of NTDs in offspring.
Authors:
Tania A Desrosiers; Christina C Lawson; Robert E Meyer; David B Richardson; Julie L Daniels; Martha A Waters; Edwin van Wijngaarden; Peter H Langlois; Paul A Romitti; Adolfo Correa; A Olshan;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2012-03-23
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  69     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-09-28     Revised Date:  2013-07-25    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  493-9     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, Campus Box 7435, University of North Carolina, Chapel Hill, NC 27599, USA. ta_desrosiers@unc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anencephaly / chemically induced,  epidemiology
Confidence Intervals
Encephalocele / chemically induced,  epidemiology
Female
Humans
Hydrocarbons / adverse effects
Hydrocarbons, Aromatic / adverse effects
Hydrocarbons, Chlorinated / adverse effects*
Infant, Newborn
Logistic Models
Maternal Exposure / adverse effects*
Mouth Abnormalities / etiology*
Neural Tube Defects / chemically induced*,  epidemiology
Occupational Exposure / adverse effects*,  statistics & numerical data
Odds Ratio
Pregnancy
Pregnancy Complications / chemically induced*,  epidemiology
Prevalence
Risk Factors
Self Report
Solvents / adverse effects*
Spinal Dysraphism / chemically induced,  epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
P30 ES010126/ES/NIEHS NIH HHS; P30ES10126/ES/NIEHS NIH HHS; R01 ES014843/ES/NIEHS NIH HHS; R24 HD050924/HD/NICHD NIH HHS; T32 ES007018/ES/NIEHS NIH HHS; U50CCU422096//PHS HHS
Chemical
Reg. No./Substance:
0/Hydrocarbons; 0/Hydrocarbons, Aromatic; 0/Hydrocarbons, Chlorinated; 0/Solvents; 8052-41-3/Stoddard solvent
Comments/Corrections
Comment In:
Occup Environ Med. 2012 Dec;69(12):934; author reply 933-4   [PMID:  22843436 ]
Occup Environ Med. 2012 Dec;69(12):933; author reply 933-4   [PMID:  22843438 ]

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