Document Detail

Maternal obesity and the risk of placental vascular disease.
MedLine Citation:
PMID:  19175965     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: While elevated maternal weight in early pregnancy is associated with a higher rate of preeclampsia, the risk of placental abruption and placental infarction is unknown. METHODS: We evaluated the risk of placental abruption, placental infarction, and preeclampsia in association with maternal weight quintile at approximately 17 weeks' gestation in 386 323 women with a singleton pregnancy who underwent maternal serum screening in Ontario. RESULTS: After adjusting for age, ethnicity, parity, diabetes mellitus, and tobacco use, the odds ratio (OR) for preeclampsia was 4.1 (95% confidence interval [CI] 3.8-4.4) comparing the highest and lowest weight quintiles. Conversely, there was a lower risk of placental abruption or placental infarction, despite further adjustment for preeclampsia, gestational hypertension and drug dependence (OR 0.81, 95% CI 0.75-0.87). CONCLUSION: Higher maternal weight in early pregnancy is associated with a higher risk of preeclampsia and a lower risk of placental abruption or placental infarction, a seeming paradox that requires further elucidation.
Taryn Becker; Marian J Vermeulen; Philip R Wyatt; Chris Meier; Joel G Ray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC     Volume:  30     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-29     Completed Date:  2009-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1132-6     Citation Subset:  IM    
Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto ON.
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MeSH Terms
Abruptio Placentae / epidemiology*
Infarction / epidemiology*
Obesity / epidemiology*
Ontario / epidemiology
Placenta / blood supply*
Pre-Eclampsia / epidemiology*
Retrospective Studies
Risk Assessment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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