Document Detail


Maternal obesity and overnutrition alter fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe.
MedLine Citation:
PMID:  20427725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In pregnant sheep, maternal:fetal exchange occurs across placentomes composed of placental cotyledonary and uterine caruncular tissues. Recently, we reported that fetal weights of obese (OB) ewes [fed a diet of 150% of National Research Council (NRC) recommendations] were approximately 30% greater than those of control (C) ewes (fed a diet 100% of NRC recommendations) at midgestation (MG), but fetal weights were similar in late gestation (LG). Transplacental nutrient exchange is dependent on placental blood flow, which itself is dependent on placental vascularity. The current study investigated whether the observed initial faster and subsequent slower fetal growth rate of OB compared with C was associated with changes in cotyledonary vascularity and expression of angiogenic factors (vascular endothelial growth factor, fibroblast growth factor-2, placental growth factor, angiopoietin-1 and -2). Cotyledonary arteriole diameters were markedly greater (P < 0.05) in OB than C ewes at MG, but while arteriole diameter of C ewes increased (P < 0.05) from MG to LG, they remained unchanged in OB ewes. Cotyledonary arterial angiogenic factors mRNA and protein expression were lower (P < 0.05) in OB than C ewes at MG and remained low from MG to LG. In contrast, mRNA levels of angiogenic factors in C ewes declined from high levels at MG to reach those of OB ewes by LG. The increase in cotyledonary arteriole diameter in early to MG may function to accelerate fetal growth rate in OB ewes, while the decreased cotyledonary arterial angiogenic factors from MG-LG may function to protect the fetus from excessive placental vascular development, increased maternal nutrient delivery, and excessive weight gain.
Authors:
Yan Ma; Mei J Zhu; Liren Zhang; Sarah M Hein; Peter W Nathanielsz; Stephen P Ford
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-04-28
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  299     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-25     Completed Date:  2010-07-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R249-58     Citation Subset:  IM    
Affiliation:
Center for the Study of Fetal Programming, University of Wyoming, Laramie, Wyoming 82071, USA.
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inducing Agents / metabolism*
Angiopoietin-1 / metabolism
Animals
Blood Vessels / metabolism
Diet / veterinary
Female
Fetal Development
Fetal Weight
Fetus / metabolism
Fibroblast Growth Factor 2 / metabolism
Obesity
Overnutrition
Placenta* / blood supply,  growth & development,  physiology
Pregnancy
RNA, Messenger / metabolism
Sheep / genetics,  metabolism,  physiology*
Uterus / metabolism
Vascular Endothelial Growth Factor A / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
P20-RR-016474./RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Angiopoietin-1; 0/RNA, Messenger; 0/Vascular Endothelial Growth Factor A; 103107-01-3/Fibroblast Growth Factor 2
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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