| Maternal obesity eliminates the neonatal lamb plasma leptin peak. | |
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MedLine Citation:
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PMID: 21262878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A neonatal peak in rodent plasma leptin plays a central role in regulating development of the hypothalamic appetite control centres. Maternal obesity lengthens and amplifies the peak in altricial rodent species. The precise timing and characteristics of the neonatal leptin peak have not been established in offspring of either normal or obese mothers in any precocial species. We induced obesity by feeding female sheep for 60 days before conception, and throughout pregnancy and parturition with 150% of the diet consumed by control ewes fed to National Research Council recommendations.We have reported that mature offspring of obese sheep fed similarly exhibited increased appetite, weight gain and obesity in response to ad libitum feeding at 19 months of age. We observed a leptin peak in lambs of control ewes between days 6 and 9 of postnatal life, earlier than reported in rodents. This peak was not present in lambs born to obese ewes. The leptin peak in lambs born to control ewes was not clearly related to any changes in plasma cortisol, insulin, triiodothyronine, IGF-1 or glucose. However, there was a significant increase in cortisol at birth in lambs born to obese ewes related to an increase in leptin in the first day of life. We conclude that the increased cortisol seen in lambs of obese sheep plays a role in disrupting the normal peak of leptin in lambs born to obese ewes thereby predisposing them to increased appetite and weight gain in later life. |
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Authors:
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Nathan M Long; Stephen P Ford; Peter W Nathanielsz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-24 |
Journal Detail:
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Title: The Journal of physiology Volume: 589 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-13 Completed Date: 2012-03-06 Revised Date: 2012-03-15 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 1455-62 Citation Subset: IM |
Affiliation:
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Center for Study of Fetal Programming, Department of Animal Science, University of Wyoming, Laramie, WY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Biological Markers / blood Birth Weight / physiology Body Weight / physiology Female Hydrocortisone / blood Leptin / blood, physiology* Obesity / blood*, complications, physiopathology Pregnancy Pregnancy Complications / blood* Sheep |
| Grant Support | |
ID/Acronym/Agency:
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HD 21350/HD/NICHD NIH HHS; P20RR016474/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Leptin; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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